cap and buffer set adapted for attachment to a plunger rod for use inside a syringe and syringe cont

专利摘要:
BUFFERS USED IN PRE-LOADED SYRINGES. There is a description of a plug adapted to be attached to a plunger rod for use inside a syringe container. The plug includes a main housing defining an open end in the rear direction and a closed front end. The open end in the rear direction is adapted to accommodate a front front end fastening portion of the piston rod. The plug also includes a central component integrally formed with the main housing adjacent to the closed front end. The central component includes a nose portion incorporating a conical tip configured to enter a mouth opening of the syringe container. The closed front end of the plug has a profile configured to cooperate with an internal surface of the syringe container wall, preventing backflow from occurring and reducing the inactive space inside the container.
公开号:BR112012025548B1
申请号:R112012025548-7
申请日:2011-03-25
公开日:2020-10-27
发明作者:Michael Vincent Quinn；Gang Ju；E. Guan；Eric Schiller
申请人:Becton, Dickinson And Company；
IPC主号:

专利说明:

RELATED REFERENCE TO RELATED REQUESTS
[001] This application consists of a continuation in part of US Patent Applications Nos. 12/133041 and 12; 133076, both filed on June 4, 2008, claiming priority over US Provisional Patent Application No. 60/941851, filed on June 4, 2007, entitled "Stopper and Plunger Rod for a Pre-Filled Syringe", and US Provisional Patent Application No. 60/950741, filed on July 19, 2007, entitled "Positive Displacement Stopper for a Pre-Filled Syringe", the complete descriptions of which are incorporated as full references. FIELD OF THE INVENTION
[002] The invention relates, in general terms, to a set of buffer intended to be used with a syringe and, more particularly, to a set of buffer showing a reduction of dead space for use with a pre-filled syringe without the presence of essentially any reflux, as in the case of injectable applications. The invention also relates to a diver plunger rod and a fixing component adapted to be fixed to the plug assembly. DESCRIPTION OF THE RELATED TECHNIQUE
[003] Pre-filled syringes, such as those referring to discharge applications, are typically filled with saline solution and are used in injectable catheters. Examples of pre-filled syringes are presented in US Patent Nos. 6361524 and 6743216, which are incorporated in this specification as references, being directed to syringe sets intended for injectable applications. During use, the nurse or technician "requests the bottom" of the syringe cap at the end of the injectable procedure. The process of requesting the bottom of the plug in the container may cause a phenomenon known as reflux. Reflux consists of reversing the flow of fluid upward through the catheter, usually caused by the return mechanism of the plug at the end of an injectable injection. Reflux can occur when the buffer having to force the introduction of additional saline by compression and having to return to its original position afterwards, causes part of that saline to be retained in the syringe. Reflux can also introduce blood into the catheter, clogging it. This reflux phenomenon can be detrimental to maintaining the catheter's functioning. Consequently, it is desirable to reduce or eliminate reflux within the syringe.
[004] Current models of plugs typically include a seal of constant diameter and interference between the plug and the constant container creating a seal that gives rise to the prevention of the flow allocated inside the container from leaking beyond the seal front of the cap. The contact pressure of the seal is determined by interference between these models, and must be sufficiently high so that the seal will not leak under the highest possible fluid pressure present inside the container. The disadvantage of this traditional model is that higher contact pressures lead to the presence of more forceful dynamic and static frictional forces. Static friction is generally referred to as the "total release" force. In addition, existing plugs typically include pointed models that are not self-centered. Because these tips are not self-centering, they do not form a positive seal inside the Luer taper when subjected to axial forces.
[005] The existing plug models have sought to find mechanisms aimed at preventing the flow of fluid from the catheter returning to the syringe by preventing new impulses from the plug that could lead to a vacuum requesting the fluid back to the syringe. These models, although efficient in terms of reflux reduction, are not able to consistently prevent all reflux originated from this type of occurrence. In addition, many of these models still have a significant amount of dead space volume. The ISO standard for inactive space requirements for a 3 ml syringe is 70 pL, for a 5 ml syringe it is 75 pL, and for a 10 ml syringe it is 100 pL. SUMMARY OF THE INVENTION
[006] There is a need in the technical scope as to the development of a plug model that will create conditions for an active seal inside a syringe container with the reduction in the chance of sliding the plunger rod going in addition to the tapering of the plug and coming into contact against the front wall. There is a need also in the current technique for a tampon model that is relatively short with the preservation of that active seal still. There is still a need in the art for a plug model that is easy to mold. There is still a need in the art for a buffer model that achieves a "positively zero" reflux yield or essentially zero with respect to zero reflux within the ISO standard criteria for dead space. The concept of an active seal involves an increase in the internal pressure present in the syringe container which will cause the front seal of the cap to have a higher contact pressure close to the inner walls of the container, maintaining a higher contact pressure. higher than the internal fluid pressure, preventing leakage of the plug seal from occurring. There is still another need in the current state of the art for a plug model that includes a feature that enables the capture and storage of potential energy before the force is released from the piston rod, effectively and consistently reducing and / or eliminating the backflow of fluid that would return to the syringe by releasing pressure on the plunger rod. There is also a need in the state of the art for a model for fixing the plunger rod that can be easily inserted into the cap of a sterile, pre-loaded syringe by applying a minimum of force to it and which can come to be securely retained inside the cap when using the syringe. There is still a need in the current state of the art for a piston rod model that employs a reduced amount of processing material, has a reduced molding cycle time, and contains high resistance with respect to side loading.
[007] The plug models described in particular create a positive displacement of the fluid out of the syringe (and therefore next to any attached catheter, for example) after the plug has reached the bottom of the syringe container, the application of force from of the plunger rod effectively and consistently reduces and / or eliminates backflow of fluid back into the syringe by releasing pressure on the plunger rod. The plug model also eliminates the possibility of "plunging along" the plunger rod inside the plug, shortening the height of the plug, and improving its molding capacity. A buffer model also meets the ISO standard for dead space, while also reaching a "positively zero" reflux (meaning close to zero). The plug is adapted to be attached to a plunger rod for use inside a syringe container.
[008] According to one aspect, the invention is directed to a plug adapted for attachment to a plunger rod for use inside a syringe container. The plug consists of a main housing defining an open end in the rear direction and a closed end in the front. The open end in the rear direction is adapted to receive a front front end fastening portion of a piston rod. The plug also includes a central component integrally formed with the main housing adjacent to the closed front end. The central component includes a projected portion containing a profile adapted to create a positive seal next to an opening for the syringe container to exit. The plug includes at least one rib extending radially outwardly around a perimeter of the main housing to form an active seal with the syringe container. An internal shoulder portion is provided on the internal surface of the main housing. The internal shoulder portion is adapted to contact a taper in the front end of the piston rod, and the contact of the internal shoulder portion with the taper causes the plug to apply a radial force close to the piston rod. plunger and the inner shoulder portion includes a first portion of cylindrical wall extending from the closed front end of the main housing. This first wall portion has a substantially flat surface profile. The internal shoulder portion further includes a second portion of cylindrical wall extending towards the open end towards the rear of the main housing. An oblique portion extends between the first and second walls. The provision of a first wall having a substantially flat surface profile results in a shorter plug containing a relatively closed dynamic sealing angle. The central component includes a front portion, a bottom portion, and a central portion positioned between the front and bottom portions, with the front portion extending beyond the front end of the main housing and the central portion being interconnected with the main housing via a flexible membrane extending between the central component and the main housing. The main housing includes at least one edge extending at the front from a front end of the main housing which is adapted to create a positive pressure chamber therein. According to one embodiment, the central component can include a bottom portion and at least one of the bottom portions of the core and an inner surface of the closed front wall including at least one concentric groove formed therein. At least one of the bottom portions of the central component and the inner surface of the closed front wall includes plug material adapted for contact with the fixing portion of the front front end of the piston rod by applying a front force close to the rod the plunger. This buffer material prevents the buffer from sliding forward and reduces the pressure volume present near the center of the buffer component.
[009] According to another aspect, the invention is directed to a plunger rod and a set of plug adapted for use next to a syringe container. The set consists of a piston rod with a front fixation end and a bottom end, extending along a longitudinal axis. The front fixation end includes a taper and a front flange extending therefrom. The set also includes a plug containing a main housing defining an open end in the rear direction, a closed front end, and a central component integrally formed with the main housing adjacent the closed front end. The rear open end is defined by means of an internal wall surface and is adapted to receive the front fixing end of the piston rod by locking the piston rod inside the plug. At least one rib is provided in the plug and extends radially outwardly around a perimeter of the main housing to form an active seal with the syringe container. A tapering with an oblique surface is formed next to an internal surface of the main housing. This taper is adapted to come into contact with the taper at the front end of the piston rod. The contact tapers form an active sealing surface cooperating together so that the plug will apply a radial force to the at least one rib and to the syringe container by applying a forward force to the plunger rod. An open space is defined in the buffer by means of the internal surface of the main housing, a portion of the central component, and the tapering on the internal surface of the main housing. The front flange extending from the front end of the piston rod extends into this open space limiting the path of the piston rod in relation to the plug.
[010] In accordance with yet another aspect, the invention comes to be concentrated to a plug adapted for fixation next to a plunger rod for use inside a syringe container. The plug comprises of a main housing defining an open end in the rear direction and a closed front end. The open end in the rear direction is adapted for admitting a fixing portion of the front front end of the piston rod. The main housing includes an internal surface. A central component is formed integrally with the main housing adjacent to the closed end. The central component includes a designed portion incorporating a conical tip configured to enter an opening for the syringe container to exit. At least one first rib extending radially outward from the perimeter of the main housing. At least one second rib extending radially outwardly around the perimeter of the main housing. With the second rib being adapted to form an active seal with the syringe container. A funnel is made available on the internal surface of the main housing. The taper is adapted to contact a corresponding taper in the attachment portion of the front front end of the piston rod. The contact tapers cooperate together to cause the plug to apply a radial force to the syringe container by applying a forward force near the plunger rod, the main housing including a side wall having a first retaining diameter inside the syringe container introducing a first internal diameter wall portion; the conical tip has a second diameter intended to contact the outlet of the container with a second portion of wall of internal diameter; and the closed front portion has a profile configured to cooperate with a tapered portion wall portion of an inner wall of the container extending between the first and second inner diameter wall portions resulting in a reduction of dead space present inside the container . The main carcass may include at least a third rib, the first, second or third ribs extending radially outside the perimeter of the main carcass, being axially spaced along the main carcass. The main housing includes at least a recessed portion extending axially into the open end in the rear direction. The recessed portion is adapted to lock the front end of the piston rod inside the plug. The tapering of the internal surface of the main housing can have a continuous contour from a portion of the side wall of the main housing close to the central component. The closed front portion has a first inclination extending from the projected portion next to the first rib slightly more staggered than a second inclination of the tapered wall portion of the syringe container extending from the opening for exiting the container next to a portion side wall of the syringe container. By applying a forward force close to the plug, the cooperation between the first and second slopes and the radial pressure of the inner container wall with respect to at least the first rib leads to the longitudinal expansion of the plug so that the projected part of the plug buffer will extend towards the outlet of the container preventing the occurrence of reflux. According to one modality, the angle of the first inclination may be approximately 1 ° smaller than the angle of the second inclination, and the longitudinal expansion of the plug by applying a forward force close to the piston rod results in an increase of the angle in approximately 2.8 ° in relation to the first inclination. According to an additional embodiment, the rear open end of the plug may be defined through a perimeter edge portion and an outer portion of this edge portion may include at least one prominence, preferably six prominences, extending to from it. According to yet another additional embodiment, the central component includes a central bottom portion defined by a side wall portion extending from a central base surface next to an intersection point between the central bottom portion and a surface tapering of the plug, this side wall portion being essentially straight along substantially its entire length. This particular model results in the reduction of machining costs in reference to the plug.
[011] In yet another aspect, the invention is directed to a syringe containing little space and essentially zero reflux. The syringe consists of a cylindrical container including a proximal end, a distal end, and a side wall containing a first inner diameter extending between the near and far ends. The distal end ends in an outlet opening having a second inner diameter smaller than the first inner diameter. The cylindrical container includes a second slope or tapered surface extending between the outlet opening and the side wall of the container. This plunger rod includes a front front fixing portion. The syringe further includes a plug containing a main housing containing an open rear end, a closed front end, and a side wall portion extending between the rear open end and the closed front end. The open end in the rear direction is adapted for admitting the fixing portion of the front front end of the piston rod and a central component formed integrally with the main housing adjacent to the closed end. The central component includes a projected portion featuring a conical tip configured for entry into the opening for exit of the syringe container. The closed front end includes a first inclined surface extending from the conical tip to the side wall portion of the plug. The first inclined surface of the plug is slightly more staggered than the second inclined surface of the cylindrical container so that an application of a forward force close to the piston rod causes the conical tip of the plug to enter the outlet opening culminating in a "positively null" reflux, while the first and second inclinations cooperate together to reduce the dead space present inside the container. The main carcass may include a first rib extending further radially outward from the perimeter of the main carcass and at least a second rib extending radially outwardly around a perimeter of the main carcass spaced at an appropriate distance from the first rib. At least the second rib is adapted to form an active seal next to the syringe container. The main housing of the plug includes an internal surface having a plug adapted to contact a corresponding taper at the front end of the piston rod. These contact tapers cooperate together so that the plug will apply a radial force to the syringe container by applying a forward force near the plunger rod. The tapering of the inner surface of the main housing can consist of a continuous contour from a side wall portion of the main housing to the central component. The main housing can include at least one recessed portion extending axially inward from the open end. in the rear direction. This lowered portion is adapted to lock the front portion of the piston rod inside the plug. BRIEF DESCRIPTION OF THE DRAWINGS
[012] Fig. 1 consists of a detailed perspective view of a plunger rod, plug, and syringe container coming according to an embodiment of the present invention; Fig. 2A consists of a perspective view of a plug coming in accordance with a first embodiment of the present invention; Fig. 2B consists of a side sectional view of the cross section of the plug of Fig. 2A taken along line 2B-2B; Fig. 3 consists of a side view of the cross section of the plug of Fig. 2A attached to a plunger rod and positioned inside a syringe container; Fig. 4A consists of a perspective view of a plug coming in accordance with a second embodiment of the invention according to an embodiment of the present invention; Fig. 4B consists of a side view of the cross section of the plug of Fig. 4A taken along line 4B-4B; Fig. 5A consists of a side view of the plug coming in accordance with a third embodiment of the invention coming in accordance with an embodiment of the present invention; Fig. 5B consists of a cross-sectional view of the plug taken along line 5B-5B of Fig. 5A; Fig. 6A consists of a perspective view of a plug according to the fourth embodiment of the invention coming in accordance with an embodiment of the present invention; Fig. 6B consists of a side view of the cross section of a plug incorporating an external model referring to Fig. 6A taken along line 6B-6B of Fig. 6A and showing an interior model coming according to the first modality of the invention shown in Fig. 2B; Fig. 6C consists of a side view of the cross section of a plug showing an external model referring to Fig. 6A taken along line 6B-6B of Fig. 6A and showing an interior model coming according to the second modality of the invention shown in Fig. 4B in combination with a type of attachment portion of a syringe plunger rod; Fig. 6D consists of a side view of the cross section of a plug showing an exterior model referring to Fig. 6A taken along line 6B-6B of Fig. 6A and showing an interior model shown according to Fig. 6C in combination with an alternative type of fixing portion of a syringe plunger rod; Fig. 6E consists of a side view of the cross section of a plug assembly showing a modified edge coming in accordance with an embodiment of the present invention; Fig. 6F consists of a side view of the cross section of a plug assembly where the edge has to be eliminated according to an embodiment of the present invention; Fig. 7 consists of a side view of the cross section of the plug referring to Fig. 6B positioned inside a syringe container; Fig. 8 consists of a side view of the cross section of the plug of Fig. 6V positioned inside the syringe container; Fig. 9 consists of a side view of the cross section of the plug according to Fig. 6D positioned inside a syringe container; Fig. 10 consists of a side view of the cross section of a plug / plunger arrangement using the plug coming in accordance with Fig. 2B during the first reflux reduction step of the invention; Fig. 11 consists of a side view of the cross section of a plug / plunger arrangement using the plug coming in accordance with Fig. 2B during the step of reducing a second reflux of the invention; Fig. 12 consists of a side view of the cross section of a plug / plunger arrangement making use of the plug coming according to Fig 2B during the step of reducing a third reflux of the invention; Fig. 13 consists of a side cross-sectional view of a plug / plunger arrangement making use of the plug coming in accordance with Fig-6C during the first reflux reduction step of the invention; Fig. 14 consists of a side cross-sectional view of a plug / plunger arrangement making use of the plug coming in accordance with Fig. 60 during the step of reducing a second reflux of the invention; Fig. 15 consists of a side view of the cross section of a plug / plunger arrangement making use of the plug coming in accordance with Fig. 60 during the step of reducing a third reflux of the invention; Fig. 16A consists of a perspective view of the piston rod pertinent to Fig. 1; Fig. 16B consists of a side view of the piston rod of Fig. 1; Fig. 16C consists of a top view of the piston rod of Fig. 1; Fig. 17A consists of an enlarged perspective view of the fastening member for the piston rod of Fig. 1 coming in accordance with a first embodiment of the invention; Fig. 17B consists of a side view of the fixing component of Fig. 17A; Fig. 18A consists of an enlarged perspective view of the fastening member for the piston rod coming in accordance with a second embodiment of the invention; Fig. 18B consists of a side view of the fixing component of Fig. 18A; Fig. 19A consists of an enlarged perspective view of the fastening member for the piston rod coming in accordance with a third embodiment of the invention; Fig. 19B consists of a side view of the fixing component of Fig. 19A; Fig. 20A consists of an enlarged perspective view of the fastening member for the piston rod according to a fourth embodiment of the invention; AFig. 20B consists of a side view of the fastening component pertaining to Fig. 20A; Fig-20C consists of a side view of the fixing component of Fig. 20A including the stop components; Fig. 21A consists of a perspective view of the piston rod including a fastening member coming in accordance with a fifth embodiment of the invention; Fig. 21B consists of a perspective view of the piston rod according to Fig. 21A including a reinforcement load located inside the fastening member; Fig. 21C consists of a side view of the piston rod of Fig. 21B; Fig. 21D consists of a side view of the piston rod of Fig. 21A with the reinforcement load being positioned within a hollow portion of the piston rod; Fig. 21E consists of a side view of the cross section taken along line 21E-21E of Fig. 21C; Fig. 21F consists of a top view of the fixing member of Fig. 21B; Fig. 22A consists of a detailed perspective view of the piston rod according to an embodiment of the invention; Fig. 22B consists of a cross-sectional view of the plunger rod of Fig. 21A taken along line 22B-22B; Fig. 23A consists of a side view of the piston rod according to a second embodiment of the invention; Fig. 23B consists of a cross-sectional view of the piston rod of Fig. 23A taken along line 23B-23B; Fig. 24A consists of a side view of the piston rod according to a third embodiment of the invention; Fig. 24B consists of a cross-sectional view of the plunger rod of Fig. 24A taken along line 24B-24B; Fig. 25 consists of a detailed side view of the individual components of the piston rod, which can be formed separately, according to an embodiment of the present invention; Fig. 26 consists of a side cross-sectional view of a piston rod and plug arrangement coming in accordance with a fifth embodiment of the invention; Fig. 27 consists of a side cross-sectional view of a piston rod and plug arrangement coming in accordance with a sixth embodiment of the invention; Fig. 28 consists of a side view of the cross section of a plug and piston rod arrangement coming in accordance with a seventh embodiment of the invention; Fig. 29 consists of a side cross-sectional view of a piston rod and plug arrangement coming in accordance with an alternative model of the invention; Fig. 30A consists of a side view of the cross section of a plug according to the eighth embodiment of the invention; Fig. 30B consists of a perspective view of the base of the plug of Fig. 30A; Fig. 30C consists of a side view of the cross section of the plug of Fig. 30A in combination with a plunger rod and positioned inside a syringe container according to an embodiment of the invention; Fig. 30D consists of a side view of the cross section of Fig. 30C including directional arrows illustrating the application of the force of the plunger rod close to the plug by means of the application of a forward force close to the plunger rod; Fig. 30E consists of a cross-sectional view of the plug of Fig. 30A illustrating the longitudinal extension and angular change of the packing or inclination of the plug by applying radial compression through the wall of the syringe container. DETAILED DESCRIPTION OF THE INVENTION
[013] For the purposes of the present description, the words "top", "bottom", "right", "left", "vertical", "horizontal", "top", "base", "side", " longitudinal ", and its derived definitions are related to the invention and based on illustrative figures. However, it should be understood that the invention may assume several alternative variations, except where expressly specified otherwise. It should also be understood that the specific devices illustrated in the attached drawings, and described in the specification, comprise exemplary modalities related to the invention. The specific dimensions and other physical characteristics related to the modalities presently described should not be considered as restrictive.
[014] Referring to Fig. 1, which shows a perspective view of a syringe, described generically as indicated by 10. The syringe consists of a plug 12 and a piston rod 14. The plug 12 and the rod of the plunger 14 are adapted for use inside the syringe container 16. The syringe 10 preferably consists of a type that is pre-loaded and sterilized for use in injectable applications. The syringe container 16 includes a spaced or front end 18 including an outlet opening and / or a mechanism for attaching a separate medical device (such as a catheter), shown in the form of a Luer 20, and an open or near open train 22 for the admission of the plug 12 and the piston rod assembly 14. Although the figures detail a plug and a separate plunger assembly, it can be seen that the characteristics of the plug may come to be integrally formed with a piston rod 14.
[015] Then, taking Figs. 2A, 4A, and 6A as a reference showing views in perspective of the positive displacement buffer coming according to several different modalities of the invention. Figs. 2B, 4B, and 6B-6D show cross-sectional views of the different types of tampon where details of the characteristics regarding the positive displacement of the tampon with respect to the syringe 10 can be readily observed, where similar elements are represented by a consistent number between the figures. The plug 12 is adapted to be attached to a plunger rod 14 for use inside a syringe container 16. The plug 12 is preferably made of an elastomeric material selected from the group consisting of natural rubber, rubber synthetic, thermoplastic elastomers, or combinations thereof. The plug 12 of the invention is usable particularly with injectable syringes such as those intended for use in connection with a catheter, already well known in the technical field.
[016] The plug includes a main housing 26 defining an open end in the rear direction 28 and a closed front end 39. The open end in the rear direction 28 is adapted for admitting the fixing portion of the front front end 31 of the piston 14. The front front end 31 fixing portion may be of a known model type capable of being fixed to the plug 12; however, the present invention includes several innovative fastening components which are adapted for use with the plug 12 of the present invention. These innovative fastening components are presented in greater detail later.
[017] The plug 12 further includes a flexible central component 32 formed integrally with the main housing 26 adjacent the closed front end 30. As shown in Fig. 3, the flexible central component 32 includes a projected portion 34 showing a profile adapted to be self-centered so that even when the breadboard 12 is not centered in the syringe container 16, a positive seal is created with an opening for the outlet of the syringe container 16, such as a surface inner 36 of a Luer 20 of the syringe container 16. As used in this report, the term "positive seal" means that the projected portion 34 of the plug 12 is seated to fully contact and seal the inner surface 36 of the Luer 20. Once that the cap 12 has traveled the total distance through the syringe container 16 and comes in contact with the inner surface next to the front wall of the inner surface 36 of Luer 20, a positive seal can be formed with the same. In one type of embodiment, the projected portion 34 has a semi-spherical shape, becoming self-centered so that even when the cap 12 is not centered in the syringe container 16, it creates a positive seal with the outlet opening of Luer 20 once the plug 12 is located at the bottom of the syringe container 16. The projected portion 34 of the flexible central component 32 can include other shapes such as the substantially tapered, cubic shape, and / or any other type of volumetric shape capable of self-centering with respect to an opening or Luer 20 of the syringe container 16. This seal prevents excess fluid from being forced out of the syringe 10 once the plug 12 has reached the bottom of the syringe container 16. Excess fluid being expelled at the end of an injection can lead to a phenomenon known as "reflux" when the plug 12 returns to its normal state and drives the excess of fluid back into the syringe 10. In the model relevant to the present invention, the seal may still build up the pressure present inside the fluid trapped between the plug 12 and the syringe container 16, which in turn will take positive displacement of the fluid once pressure is released. This positive displacement of the fluid to prevent reflux is discussed in more detail below.
[018] The flexible central component 32 includes a front portion 38, a bottom portion 40, and a central portion 42, positioned between the front portion 38 and the bottom portion 40. The front portion 38 protrudes from the housing main 26, such as along a longitudinal axis of the main housing 26. The flexible central component 32 can be interconnected with the main housing 26 via a flexible membrane 44 extending between the flexible central component 32 and the main housing 26. The bottom portion 42 of this flexible central component 32 contacts the front front end fastening portion 31 of the piston rod 14. The innovative design of the self-centered projected portion 34 allows for sealing when a small volume of force is applied to the buffer 12 along the integral tolerance bands of the buffer 12 and the syringe container 16.
[019] As discussed above, the sealing surface in the projected portion 34 contacts the inner surface 36, or the bottom surface of the conical Luer 20 near the front end of the syringe container 16, as shown in Fig. 1 Since it is possible that the inner surface 36 of the Luer 20 and the projected portion of the plug 12 will not be perfectly concentric, in one type of embodiment, the projected portion 34 of the plug 12 may be able to move laterally in a way to make complete contact with the inner surface 36 of the Luer 20. In an additional type of embodiment, the flexible central component 32 and the flexible membrane 44 can allow the projected portion 34 to move in a substantially lateral direction. In yet another embodiment, the substantially spherical shape of the projected portion 34 ensures full contact between the projected portion 34 and the inner surface 36 of the Luer 20 even when the projected portion 34 is rotated or deflected prior to making the contact.
[020] The innovative model of the plug 12 of the present invention consists of an improvement over the existing plugs since these current plugs present a typically tapered spout that work with the seal only when the plug and the container are perfectly concentric. In previous models, if two components do not appear to be exactly aligned, an appropriate seal will not occur unless higher forces are applied next to the plug to deform it leading to a configuration that will provide a seal with the afu - Luer container denaturation.
[021] According to a first embodiment of buffer 12, according to the illustration provided in Figs. 2A, 2B, and 3, and a second embodiment of the plug, according to the illustration given by Figs 4A and 4B, the main housing 26 includes at least one rib 42 extending radially outwardly and substantially around the main housing perimeter 26. This first rib 46 is adapted to form an active seal with the syringe container 16. According to the use given in this report, the term "active seal" means that the sealing pressure increases between the first rib 46 of the plug and the inner surface of the syringe container 16 during the extension of the force carried out next to the piston rod 14. In one type of embodiment, the main shell 26 includes a second rib 48 extending substantially around from the perimeter of the main housing 26. The first rib 46 and the second rib 48 can be axially spaced along the length of the main housing 26.
[022] An aspect of the first embodiment buffer model illustrated in Figs. 2A, 2B, and 3 consists of an edge extending at the front 50 from the closed front end 30 of the main housing 26. Depending on the elasticity and / or flexibility of the edge extending to the front 50, the edge extending for the front part 50 it has the ability to deform radially internally and substantially coming into contact with an external portion 52 of the main housing 26. Such deflection can occur by inserting the plug 12 inside the container syringe 16 to form an air receptacle 53 trapping the air bubble inside. The air bubble trapped inside the air receptacle 53 meets the backflow capabilities of the present invention according to the discussion given in detail below. By inserting the plug 12 into the syringe container 16, the leading edge 50 can be adapted to create positive pressure inside the syringe container 16.
[023] In one type of embodiment, the main housing 26 includes a recessed portion 55 extending axially internally from the open end in the rear direction 28. The recessed portion 55 is adapted to engage the front front end attachment portion 31 of the piston rod 14 for locking the front front end fixing portion 31 of the piston rod 14 inside the plug 12. According to a type of embodiment, as shown in Fig. 3. the recessed portion 55 may include a taper reverse 56 adapted to act in cooperation with at least one deflection joint 130 associated with the front front end fixation portion 31 of the piston rod 14.
[024] The plug 12 of the present invention can be further adapted to reduce or prevent reflux at half rate. The flow at half rhythm can occur if the discharge solution is not fully supplied with the doctor, not effectively filling while moving the plug. Traditional syringe models will generally reflect in the form of frictional force near the outside diameter of the plug with the piston rod forces near the center of the plug causing the "projected" part of the plug to stretch. In order to overcome the presence of static and dynamic friction to induce the movement of the plug, the piston rod force must be greater than the frictional force, this lack of balance in the force is overshadowed by the return pressure of the buffer fluid and stretch. The difference is small, but measurable. As shown in Fig. 3 of the present application, an interval 94 is provided between a bottom portion 93 of the flexible central component 32 of the plug 12 and the lining 95 of the front front end 31 fixing portion of the piston rod 14. Due to the presence of this gap 94 and the flexibility of the flexible membrane 44 securing the flexible central component 32 next to the main plug housing 26, the flexible central component 32 is capable of deflecting nearby and storing potential energy that will be released in the form of positive displacement as soon as the force of the piston rod 14 has ceased. Consequently, when using syringe 10, depending on the gap 94, the plunger rod 14 does not directly apply a forward force to the flexible central component 32. Instead, the plunger rod 14 applies a forward force to the lateral portion inside the plug 12, which in turn applies a pulling force to the flexible central component 32 via a flexible membrane 44. Thus, during the application of pressure near the piston rod, the flexible central component 32 is slightly contracted within the range 94. Once the front force has been suspended, the flexible central component 32 continues in this forward movement and prevents the appearance of reflux at half a pace.
[025] According to one aspect of the invention, as described in Figs. 2B, 3, and 4B, the inner portion of the main housing 26 includes an inner surface 132 having a taper 198 adapted to contact a taper 196 near the front front end 31 fixing portion of the piston rod 14. These tapers contact 196, 198 cooperate together so that the cap 12 applies a radial force to the syringe container 16 to form an active seal between them by applying a forward force close to the piston rod 14. The aspect of the active seal of the invention is discussed in detail below.
[026] According to a second embodiment of the invention, as illustrated in Figs. 4A and 4B, the flexible membrane 44 can extend from the flexible central component 32 next to the side wall portion 57A of the main housing 26 ending at the first rib 46A. In one type of arrangement, the flexible membrane 44A, the first rib 46A, and the side wall 57A are integrally formed. In an additional configuration, there is no inclusion of the edge extending forward 50 of the first modality.
[027] According to a third embodiment of the invention, as illustrated by Figs. 5A and 5B, an active seal achieves the same result achieved by the previously discussed modalities, but containing a differentiated mechanism, commonly referred to as a "drill-edge seal", when referring to hydraulic applications. The plug, generally referred to as 254, includes this type of drill edge seal. The front seal 256 of the plug 254 is located next to an advanced edge of a flexible joint 258. The initial sealing pressure is generated by interference of the flexible joint 258 with the wall of the syringe container 16, as shown in Fig. 1. When the pressure increases in the syringe container 16, this pressure applies an external radial force close to the inner part 259 of the flexible joint 258. This outward force will increase the force responsible for the pressure of the seal 256 against the wall syringe container 16.
[028] Referring now to Figs. 6A-6F and 7-9 showing buffer 12 according to a fourth embodiment of the invention. In this embodiment, the plug 12 includes a main housing 26 having a closed front end 30. The main housing 26 can include an open end in the rear direction 28 adapted for admitting a fixing portion of the front front end 31 of the piston rod 14. As previously stated, the front front end fixing portion 31 is capable of securing the plug 12. The main housing 26 includes a first housing portion 60 containing a first diameter D1, shown by Fig. 6B, and a second carcass portion 62 containing a second diameter D2, shown according to Fig. 6B, being larger than the first diameter of the first carcass portion 60. A shoulder 64 extends around the perimeter of the first carcass portion 60 of the main housing 26. Preferably, this shoulder 64 extends radially in the outward direction with respect to the first housing portion 60.
[029] According to what was previously established with respect to the description of the first embodiment, a flexible central component 32 comes to be integrally formed with the main housing 26 adjacent to the closed front end 30. The flexible central component 32 includes a projected portion 34 extending from the closed front end 30 which is adapted to contact an inner surface 36 of an outlet opening, such as a Luer 20 of the syringe container 16. The flexible central component 32 can be formed from a flexible material and the projected portion 34 can include a semi-spherical self-centered profile for creating a positive seal with the Luer 20 near the front end of the syringe container 16.
[030] Buffer 12 of the fourth embodiment, shown in Figs. 6A-6E differs from the first embodiment in that the plug 12 includes at least one perimeter edge 66 extending from the second housing portion 62 towards the front end 30 of the main housing 26. This perimeter edge 66 cooperates with the shoulder 64 to capture the air receptacles or an air bubble 68 between them by inserting and / or moving the plug 12 inside and through the syringe container 16. In this way, by releasing a forward force near the piston rod 14, the fluid remaining inside the syringe container 16 is forced through the Luer 20 through its positive displacement. As shown in detail via Figs. 6B- 6D, the edge 66 may include an inner surface 70 and an outer surface 72 may be formed from an elastic and / or flexible material capable of deflecting radially inwardly. The inner surface 70 of the perimeter edge 66 can substantially contact the boss 64 to capture at least one air bubble / receptacle 68. In one type of embodiment, the edge 66 includes a nozzle portion 74 and a tail portion 76. The nozzle portion 74 may include a first rib 77 or cushion extending outwardly. An outer surface 77 'of the first rib 77 may be adapted to contact an inner surface 78 of the wall of the syringe container 16, shown in Fig. 1. This first rib 77 establishes a simple line of contact between the perimeter edge 66 and the inner surface 78 of the syringe container wall 16, as shown in Figs. 7-9. This first rib 77 functions to maintain an outer surface 69 of the perimeter edge 66 adjacent to the tail portion 76, positioned at a predetermined distance from the inner surface 78 of the wall of the syringe container 16. This minimizes the contact area present between the perimeter edge 66 and the syringe container 16 reducing the breaking forces and reducing the static friction of the perimeter edge 66 with respect to the syringe container 16. The particular model referring to the perimeter edge 66 can enable to a clearer observation as to the establishment of the dosage. In one type of embodiment, the perimeter edge 66 has a relatively linear shape and extends cylindrically around the first carcass portion 60 of main carcass 26. According to another embodiment, the inner surface 70 of perimeter edge 66 does not come to necessarily contact the main housing 26 to form the receptacle or air chamber 68, but it is close enough to the main housing 26 so that the surface tension preserves the closed chamber 68, capturing air bubbles in it.
[031] As shown in Figs. 6B-6D, the perimeter edge 66 of the plug 12 is sized to have a predetermined contact area 80 for cooperation with the shoulder 64. The predetermined contact area 80 is adapted to form a predetermined enough enough gap for the capture of air, allowing pressure to communicate from the air chamber to the fluid chamber.
[032] Fig. 6E shows a modification of plug 12 of the fourth embodiment in which the edge 66 has a predetermined length L1 which is less than the length L2 of the perimeter edge 66 pertinent to Figs. 6B-6D and is less than the height H1 of the shoulder 64 so that the predetermined contact area 380 contacts a base surface 365 of the shoulder 364 to form the pneumatic pressure chamber 368.
[033] According to another provision, as shown in Fig. 6F, an automatic pressure chamber 468 can be created basically through cooperation with the shoulder extending radially 464 with the inner surface 468 of the syringe container 16. In this type of configuration, the nozzle 467 of the boss 464 does not actually have to contact the inner surface 478 of the syringe container wall 16 in order to create an automatic pressure chamber 468, however it needs to be located only within a certain distance with respect to this inner surface to close the automatic pressure chamber 468.
[034] Taking Figs. 6A-6F, the flexible central component 32 of the plug 12 of the invention includes a front portion 82 extending above the main housing 26, a bottom portion 84, and a central portion 86 positioned between the front portion 82 and the bottom portion 84 The flexible central component 32 comes to be interconnected with the main housing 26 and, in particular, with its first carcass portion 60 via a flexible membrane 44 extending between the central portion 86 of the flexible central component 32 and the first housing portion 60 of the main housing 26. The innovative model of the self-centered projected portion 34 allows a seal to be made between the projected portion 34 and the inner surface 36 of a Luer or opening 20 when a small volume of force is applied next to the plug 12 and over a whole tolerance range of the plug 12 through the piston rod 14 and the syringe container 16. According to the previous discussion regarding the first modally, the shape of the partially spherical surface of the projected portion 34 of the flexible central component 32 ensures full contact between the projected portion 34 and the inner surface 36 of the Luer 20, even when the projected portion 34 has rotated or deflected before making contact.
[035] The flexible membrane 44 and the receptacle / air bubble 68 are adapted for the storage of energy, so that by releasing positive pressure close to the piston rod 14 and releasing the seal between the projected portion 34 of the flexible central component 32 and the inner surface 36 of the Luer 20, the release of this potential energy forces the fluid inside the syringe container 16 to travel through the Luer 20 and any connected catheter.
[036] According to the fourth embodiment of this invention, main housing 26 includes at least a second rib 88 extending substantially radially outward and substantially around a perimeter of the second housing portion 62 of main housing 26. This second rib 88 is adapted to form an active seal close to the inner surface 78 of the syringe container 16. At least one receptacle / air bubble 68 is positioned in a forward position with respect to the second rib 88. The main housing 26 may include a third rib 90 such that the second rib 88 and the third rib 90 extend radially outwardly around the perimeter of the outer diameter D2, as shown in Fig. 6B of the second housing portion 62 of the main housing 26, axially spaced along the second carcass portion 62.
[037] As shown in Figs. 6B-6F and in Figs. 7-9, the main housing 26 of the plug 12 can include at least one recessed portion 55 extending axially into the rear open end 28. This recessed portion 55 is adapted for locking the front front end attachment portion 31 of the piston rod 14 inside the plug 12. According to one aspect, the recessed portion 55 may include a reverse taper 56, as shown, for example by Fig. 7, adapted to act in cooperation with the attachment portion of the front front end 31 of the piston rod 14. Various models of the front front end 31 fixing portion, coming in accordance with the present invention are discussed in detail below.
[038] As shown in Figs. 6B and 7, the main housing 26 may further include an inner surface having a taper 198 adapted to contact the taper 196 near the front front end fixing portion 31 of the piston rod 14. These contact tapers 196, 198 cooperate together so that the plug 12 applies a radial force close to the syringe container 16 to give an active seal with it by applying a forward force close to the piston rod 14.
[039] According to another aspect of the invention, as detailed by Figs. 6C, 6D, 8 and 9, the funnel 199 of the inner surface 132 of the main housing 26 can be a continuous contour of a portion of the side wall 57 of the main housing 26 to the flexible central component 32. This contour funnel 199 comes to be adapted for cooperation with the taper 196 next to the front front end fixing portion 31 of the piston rod 14, so that the plug 12 applies a radial force next to the syringe container 16 to form an active seal with it by applying a forward force near the piston rod 14.
[040] Increasing pressure inside the syringe container 16 will cause the closed end of the front end 30 of the plug 12 to present a pressure of greater contact with the inner surface 78 of the wall of the syringe container 16, preventing the occurrence leaks near the seal of the cap 12 and the syringe container 16. The active delivery of the present invention solves this problem by employing a lower contact pressure between the cap 12 and the syringe container 16 when they are low fluid pressures are present in the syringe container 16, and higher contact pressures when the fluid pressure increases, such as during the forward movement of the plunger rod 14 and plug 12 through the syringe container 16.
[041] In a type of modality, the active seal is achieved by the interaction of the fixing portion of the front front end 31 of the piston rod 14 and the interior of the plug 12. According to a modality, as shown in Fig. 6B , the attachment portion of the front front end 31 of the piston rod 14 includes a front forward surface taper 196, corresponding to a taper 198 present inside the plug 12. During use when the piston rod 14 comes to be requested, an advanced forward edge applies force to the inside of the plug 12. Due to the shape of the taper of the two surfaces 196, 198, the plunger rod 14 imposes a force that prompts the pushing of the plug 12 in the syringe container 16 and a force that substantially prompts outward in a radial direction. The outward force advances the buffer plug 12 ahead of the second rib 88, and towards the walls of the syringe container 16 increases the sealing pressure. Likewise, as shown in Figs. 6C and 6D, the taper 196 next to the front front end fastening portion 31 of the piston rod 14 imposes a force on the continuous contour taper 199 of the inner surface 132 of the main housing 26 so that the plug 12 applies a radial force next to the syringe container 16 to give an active seal with it by applying a forward force close to the plunger rod 14. The high forces of the plunger stem are caused by the high pressure in the syringe container 16, so that the contact pressure with it will increase as the pressure in the syringe container 16 increases.
[042] In a later embodiment, the perimetric edge 66 of the plug 12 also acts as a drill-edge seal. As the fluid pressure increases, with the increase in air pressure inside the receptacle / blister 68, the contact pressure at the edge near the interface of the plug 12 and the syringe container 16 increases, improving the sealing performance. advantage of this active seal is due to the application of the force of the piston rod 14 only next to the second or front rib 88, allowing the third or bottom rib 90 to be "pulled" forward during the injections. The traction will also stretch the material of the third rib 90 or the bottom rib reducing the effective force next to the syringe container 16 and further reducing the frictional forces.
[043] The plug model of the present invention is intended to prevent reflux by generating the positive displacement of the fluid out of the front end of the syringe container (and into any catheter being incorporated) after plug 12 has reached the base of the syringe container 16 with the release of force from the piston rod 14. The characteristics of the plug 12 that act to generate this positive displacement consist of the sealing next to the projected portion 34 of the plug 12, the relative movement or flexing of the cap 12 between the projected portion 34 and the second sealing or front rib 88, and the potential energy in the form of pressurized fluid captured and stored before the release of the force from the piston rod 14. The relative movement of the second rib 88 , with respect to the projected portion 34 of the plug 12, it is reached by means of the flexible membrane 44 that makes the connection of the second rib 88 or external front rib that of the flexible central component 32 and the projected portion 34. The stored energy is obtained through both the flexible membrane 44 and the air receptacle or air bubble 68, which is captured under the perimeter edge 66 just ahead of the second rib 88.
[044] The particular model of the fourth embodiment of buffer 12 of the present invention has several advantages. For example, since the perimeter edge 66 can be substantially linear, without the presence of any radial flanges, the creasing of the perimeter edge 66 is reduced and / or eliminated. In particular, the provision of the shoulder 64, the first carcass portion 60 of the main carcass 26 of the buffer allows 666 to have a relatively straight shape, with the flexibility and / or elasticity of the perimeter edge 66 allowing for flexing in the internal direction providing a contact area 80 of the perimeter edge 66, without deformation of the perimeter edge 66 itself, and contacting the shoulder 64. Another advantage of this model is the simplification of the manufacture of the plug 12. As only a molding machining plate comes required at the base of the mold, there is a reduction in the cost of machining.
[045] Adding the portion or cushion extending outside the first rib 77 along the perimeter edge 66 minimizes the area of the perimeter edge 66 in contact with the inner surface 78 of the syringe container 16. This reduced contact area decreases forces of rupture and static friction and also provides with a clear indication of the dosage establishment. Finally, the model of interference and extension of the perimeter edge 66 is such that it maintains the appropriate interval for the capture of air and allows the presence of pressure communication from the pneumatic chamber to the fluid chamber.
[046] An active seal of the plug 12 within the syringe container 16 can be further achieved by means of the front front end fixing portion 31 of the piston rod 14, as described below, in combination with the particular inner model of the plug 12. The front front end fixing portion 31 is adapted for use with any of the previous plug modes described in this report. The invention is particularly useful in situations where the syringe 10 is pre-loaded and sterilized with the buffer plug 12 being inserted into the syringe container 16 prior to fixing the plunger rod 14 next to the buffer plug 12.
[047] As illustrated in Figs. 16A-16C, the piston rod 14 can include an elongate member 124 having a front end 126 and a bottom end 128 extending along a longitudinal axis AX, as shown in Fig. 16B. At least one deflection joint 130 may come to be associated with the front end 126 of the elongated component 124. The articulation arm 130 may be able to deflect radially inwardly when introducing the piston rod 14 into the plug 12, and deflecting outwardly contacting the inner surface 132 of the buffer plug 12, as shown in Fig.3, after introduction into the buffer plug 12 by locking the piston rod 14 inside the plug 12. Figs. 16A-16C illustrate two deflection joints 130, however, any number of deflection joints 130 can be provided as necessary for the secure fixation of the piston rod 14 inside the plug 12.
[048] Taking Fig. 3 as a reference again, when the piston rod 14 is introduced in the plug 12, the deflection arms 130 in the piston rod 14 deflect and / or the deformation of the plug 12 takes place, allowing the that the deflection joints 130 move towards a recessed space 134 inside the plug 12. When the deflection joints 130 enter the recessed space 134, the piston rod 14 is locked in this position and prevented from separating from the plug 12. When a user proceeds to aspirate the inside of syringe 10, the deflection joints 130 next to the plunger rod 14 will interact with the recessed surface 136 of the plug 12 inside the plug 12, preventing the plunger rod 14 from project out of the cap 12. The base surface 133 of the deflection joint 130 can be tapered to match the shape of the recessed surface 136 of the cap 12. Deflection joints 130 can be implemented according to div various models, as discussed in detail below.
[049] According to a first embodiment, as shown in Figs. 17A-17B, the front end 126 of the elongated component 124 includes a main component 140 extending from the front surface 144 of the front end 126. The main component 140 includes a margin component 142 extending along a front surface 144 of the same. The deflection joints 130 may extend from a base surface 146 of the margin component 142 in a substantially downward direction. At least one first stop component 148 can be provided for limiting the deflection of the deflection joints 130 during the introduction of the piston rod 14 into the plug 12. This first stop component 148 can be positioned adjacent to a rear portion 150 of the component principal 140.
[050] The margin component 142 is formed, preferably from an elastomeric material capable of forming an active seal with an internal surface of the plug 12, as shown in Fig. 3. A reinforcement material 153 can also be made available near the contact area of the deflection joints 130. In addition, as shown in Figs. 16A, 16C, and 17A, the margin component 142 and the main component 140 may include a hollow portion 156 defined at least by a side wall 158. The side wall 158 has a plurality of ribs extending inwardly 159 turned radially inward towards the center of the hollow portion 156. According to one embodiment, this hollow portion 156 may come into contact with a bottom portion of the flexible central component 32 within the plug 12.
[051] According to a second embodiment, as illustrated in Figs. 18A-18B, at least one deflection joint 160 extends radially outwardly from a central portion 162 of main component 140. In this embodiment, deflection joint 160 may consist of a continuous component extending through an opening in the portion central 162 of main component 140. A hollow portion 166 is also available next to main component 40 and margin component 142 of this modality. The edges 168 of the deflection joint 160 may also be formed from an appropriate reinforcement material. A first stop member 170 extends backwards from a base surface 173 of margin component 142 limiting deflection of the joint in an opposite direction, such as during the syringe aspiration procedure 10.
[052] According to a third modality, as illustrated in Figs. 19A-19B, at least one deflection joint includes a pair of deflection joints 174 extending in a downward direction and radially outward from the base surface 173 of margin component 142. In this embodiment, a first stop component 176 extends outwardly from a rear portion 150 of main component 140. A second stop component 178 extends downwardly from an outer edge 179 of margin component 142 limiting the deflection of deflection joints 174, such as during the aspiration procedure. The edges 180 of the deflection joints 174 are formed from an appropriate reinforcement material.
[053] According to a fourth modality, as illustrated by Figs. 20A-20C, the front end 126 of the elongate member 124 includes a bottom surface 126A incorporating a main member 140 extending therefrom. The main component 140 includes a margin component 142 extending along a front surface 144 thereof. In this embodiment, at least one of the deflection joints includes a first hinge portion 182 extending from the bottom surface 126A parallel to the main component 140 and a second hinge portion 184 attached to a front portion 186 of the first portion of pivot 182 extending in a rearward and outward direction with respect to the first pivot portion 182. A stop component 188, as shown in Fig. 20C, can be provided to limit the deflection of the second pivot portion 184 during the introduction of the piston rod 14 inside the plug 12. This stop component 188 is positioned adjacent an external surface 190 of the first hinge portion 182 next to a location adjacent to an internal surface 191 of the second portion of article circulation 184. The portions of the second hinge portion 184 may include reinforcement material 189 as needed. In addition, the base surface 193 of the second hinge component 184 can be flat or tapered as desired, depending on the shape of the lowered portion of the coupling surface 136 of the plug 12.
[054] These double deflection joint portions 182, 184 can deflect from the base of the front end of the piston rod 14 and from the top of the joint fixed near the base of the front end geometry. During introduction, a normal load is exerted on the surface of the outer side of the second hinge portion 184. When pressure is exerted near the front or top portion 186 of the second hinge portion 184, the first hinge portion 182 deflects internally. As the pressure moves the surface of the second hinge portion 184 down, this second hinge portion 184 will begin to deflect. Deflection is greatest when both articulation portions 182, 184 reach maximum deflection. During suction, a compressive and / or torsional load is applied to the hinge portions 182, 184 and the first hinge portion 182 will begin to deflect inward, while the second hinge portion 184 will penetrate the recessed surface. of the plug, such as the recessed surface 136, shown in Fig. 3. The deflection, however, is restricted to the contact between the second hinge portion 184 and the inner surface 132 of the wall of the plug 12. According to the discussion above, a stop component 188 can be made available to reduce the stresses present in the hinge portions 182, 184 by limiting the deflection of the hinge portions 182, 184 where necessary, making the deflection independent of surface pressure during insertion and after there is the contact between the stop member 188 and the second hinge portion 184.
[055] The modality shown by Figs. 20A-20C may further include an opening 192 in the main component 140 and the margin component 142. This opening 192 is defined by a circular side wall 194 and a plurality of ribs 195 extending inwardly from this side wall circular 194 directed to opening 192.
[056] According to a fifth modality, as illustrated in Figs. 21A- 21F, the clamping portion, generally indicated by 200, of the piston rod 14 may include a deflection joint 204, which may include a simple circular deflection joint or a plurality of deflection joints extending from the end front 126 of the elongated component 124. This deflection joint 204 defines a space 206, and during the attachment of the piston rod 14 inside the plug 12, the deflection joint 204 deflects internally to the space 206. When the deflection joints 204 have reached maximum deflection and are housed in the recessed space 134 inside the plug 12, a load 208 can be introduced in this space 206 to support the deflection joint 204 and prevent it from dismounting and separating from the plug while using syringe 10. According to one embodiment, as shown in Figs. 21D-21E, the elongate component 124 includes a hollow portion 210 and the load 208 is pre-molded within this hollow portion 210. After fixing the piston rod 14 next to the plug 12, an actuation force is applied inside the hollow portion 210 forcing the load into the space 206. Alternatively, the load 208 can be molded separately and subsequently introduced.
[057] Another aspect of the present invention is the innovative piston housing model shown in Figs. 22A-22B, 23A-23B, 24A-24B, and 25. The piston rod 14 is preferably made from a rigid thermoplastic material. This model, as discussed in greater detail below, consists of an elongated hollow piston rod housing in which the hollow portion comes to be defined by means of a plurality of lobes extending longitudinally, with the provision, preferably of an odd amount of lobes. In traditional models of four-rib plungers in solid casing, a user can apply a lateral load during the suction procedure that may be standard at the edge of a rib, leading to minimal deflection of the lateral load, or normal to the region between the ribs , that is, at 45 ° of the rib, leading to maximum deflections of the lateral load. The present invention introduces a plunger housing comprising an elongated housing portion 234 containing a front end 236, a bottom end 238, and a side wall portion 239 extending along a longitudinal axis present between the front end 236 and the bottom end 238. The side wall portion 239 consists of a plurality of lobes extending longitudinally 240 defining an inner hollow portion 242. A fastening member 24 is secured next to the front end 236 being adapted for fixing the plunger rod 14 next to plug 12. A tapering member 246 is attached to the bottom end 238 of the elongated housing portion 234 for tapering the inner hollow portion 242, providing with a pressure area to the thumb 248 intended for application of a force close to the piston rod 14 during use.
[058] The longitudinally extending lobes 240 preferably consist of an odd number of lobes spaced substantially equidistant from each other. According to a type of modality, as shown in Figs. 23A-23B, the plurality of longitudinally extending lobes 240 consist of a three-lobed model 250 positioned at an approximate 120 ° angle with respect to each other. According to yet another embodiment, as shown in Figs 22A-22B, the plurality of lobes extending 240 totals five of them, forming a model of five lobes 251, with lobes 240 being spaced substantially equidistant from each other. The lobes are positioned together to form a substantially uniform lateral loading deflection of the piston rod 14. The provision for an odd number of lobes 240 decreases the expected deflection when the load is applied close to the region between the lobes 240 through the introduction of a lobe on the opposite side supporting the reaction load. The present invention further includes four-lobed hollow elongated plunger models 252, as illustrated in Figs. 24A-24B. Because the piston housing portion 14 includes a hollow portion 253, the advantages associated with the hollow model, as discussed earlier, should also be present in the four-lobe model 252. The co model also provides additional stiffness next to the portion casing 234 of the piston rod 14 and several improvements, such as reducing production costs, facilitating manufacturing procedures, and the like according to the detailed discussion provided below.
[059] The piston rod 14 of the invention can be manufactured according to the following processes. In a first process, the elongated housing portion 234 and the front end fastening member 244 are integrally molded from the same material. The piston rod 14 is designed to have an internal hollow portion 242 so that the core pin can be driven behind the central part of the piston rod 14 during injection molding. This allows the piston rod 14 to be molded "upright", resulting in a reduction in cycle time due to additional cooling in the core pin and an increase in volume due to the increase in the number of cavities . To effect the tapering of the opening of the core pin or the internal hollow portion 242 in the pressure area / side of the thumb 248, a soft touch surface disk 249 can be fixed in the pressure area of the thumb 248 by comfort during the injection process.
[060] According to a second process, as shown in Fig. 25, the piston rod 14 can be manufactured in three separate parts. The fastening component 244 can be injection molded, the elongated housing portion 234 of the piston rod 14 can be extruded or injection molded, and the tapering component 246 or thumb pressure disc 248 can be manufactured by means of of a stamping molding process. The fastening component 244, the elongated housing portion 234, and the thumb pressure disc 148 can be formed from differentiated materials to improve performance where needed. For example, a more expensive material can be used to mold the front fastening component 244 for improved performance, and a soft-touch elastomer such as the thumb pressure disc 248 can be used. Extruding the housing portion 234 of the plunger 14 it allows for additional geometries of cross sections that would provide with uniform lateral loading deflection and would allow for ergonomic improvements that would otherwise encounter limitations due to the dividing lines present in the mold. In addition, the use of an extrusion process for the carcass portion makes it possible to produce portions of carcasses of different lengths intended for use with different syringe container lengths syringe container 16 from a simple extrusion device .
[061] In the fixing arrangements of Figs. 17A-17B, 18A-18B, 19A-19B, and 20A-20B, each of these embodiments includes a main component 140 containing a margin component 142 extending along one of its front surfaces 144, where the margin component includes a taper 196 adapted to contact a corresponding taper 198 inside the plug 12, as shown in Fig. 2B for applying a radial force to the plug 12 by applying a forward force to the piston rod 14. In the arrangement shown in Figs. 21A-21F, the deflection joint 204 includes a taper 213 at its front end 214 adapted to contact a corresponding taper 198 present inside the plug 12 to apply a radial force close to the plug 12 by applying a forward force to the piston rod 14.
[062] The plug model of the present invention is intended to prevent the occurrence of reflux by creating a positive displacement of the fluid next to the incorporated catheter after the plug 12 has reached the bottom of the syringe container 16 with the release of force from the piston rod 14. The characteristics of the plug 12 acting to create this positive displacement consist of the sealing next to the projected portion 34 of the buffer 12, flexing or causing relative movement of the plug 12 between the projected portion 34 and the first sealing rib or front rib 46, and generating a mechanism where the potential energy in the form of pressurized fluid can be captured and stored before the release of force from the piston rod 14. The relative movement of the first rib 46 with respect to the projected portion 34 of the plug 12 is achieved by means of the flexible membrane 44 which connects the first external rib 46 to the central flexible component level 32 and the projected portion 34. The stored energy is reached through both the flexible membrane 44 and the air bubble or air receptacle chamber 53 which is trapped under the seated edge extending ahead 50 just ahead of the first rib 46.
[063] As illustrated by Figs. 10-12, positive displacement or a reflux prevention method inside the syringe container includes the following steps. The first step provides with a plug 12 containing a main housing defining an open rear end 28 and a closed front end 30. The rear open end 28 is adapted to accommodate a front end end fastening component 31 of a piston rod 14 present therein. A flexible central component 32 is interconnected with the main housing 26 via a flexible membrane 44 integrally formed with the main housing 26 adjacent to the closed front end 30. The flexible central component 32 includes a projected portion 34, preferably having a profile, as discussed earlier, being self-centered and adapted to create a positive seal containing an inner surface of the Luer 20 of the syringe container 16. The method further includes the step of inserting the front front end 31 fastening member of the plunger rod 14 present inside the rear open end 28 of the plug 12. The application of force next to the plunger rod 14 ahead the plug 12 for the syringe container 16 until the projected portion 34 of the flexible central component 32 contacts the inner surface 36 of the syringe container Luer 20 forming a seal and preventing the fluid from flowing into it o Luer 20. The application of additional force close to the piston rod 14 to compress the projected portion 34 requires at least one rib 46 present inside the syringe container 16 to advance and compress the trapped air, forcing the pressure inside to increase of the air receptacle 53. The final step of the method consists of releasing the force on the piston rod 14 by releasing the seal between the projected portion 34 and the inner surface 36 of the Luer 20, where the frictional force keeps the rib 46 in one advanced position inside the syringe container 16 so that the high pressure inside the air receptacle 53 promotes the thrust of any fluid retained through the Luer 20 and next to any incorporated catheter.
[064] Figs. 2A-2B and 3 show a plug model in which the plug 12 includes at least one edge extending ahead 50 from a closed front end 30 of the main housing 26, the step of applying a force for advancing the plug 12 inside the syringe container causes this edge 50 to deflect inwardly with respect to the main housing 26 of the plug 12 coming in contact substantially, or coming to be located substantially at a predetermined distance with respect to one of its external portions 52, forming an air receptacle 53 trapping air in the room. The step of applying additional force next to the piston rod 14 to compress the projected portion 34 causes the flexible membrane 44 to be stretched. The step of releasing force on the piston rod 14 releases the force near the flexible membrane 44, causing any fluid that has been retained to be propelled through a Luer 20 or opening for exit and next to any incorporated catheter.
[065] Figs. 4A and 4B present a plug model that is not based on a flexible outlet for the trapping of an air bubble serving in the energy storage to force the displacement of any type of fluid through the Luer 20. On the contrary, this model is based only in the flexibility of the membrane 44A by connecting the flexible central component 32 next to the main housing 26 of the plug 12 to capture the pressure energy and return it as soon as the release of the force occurs from the piston rod 14. The characteristics Additional features that can trap an air bubble include other shapes of recessed molding receptacles or grooved channels in the plug lining.
[066] Figs. 5A and 5B illustrate yet another model of buffer 254, according to the invention. This type of model, discussed in detail below, features a drill edge seal intended for sealing the container. The front seal 256 of the plug 254 is located on the forward edge of the flexible joint 258. The initial sealing pressure is generated by interference the joint with the container wall. When the pressure in the syringe container 16 increases, an external radial force is applied to the inside 250 of the flexible joint 258. This outward thrust will increase the force effected by the seal pressing against the wall of the container.
[067] A method for positively displacing the fluid and preventing reflux from occurring inside the syringe container using the plug model of Fig. 6C is also made available by the present invention with illustration given by Figs. 13-15. This method consists of the steps of providing a plug 12 containing a main housing 26 incorporating a closed front end 30. The main housing 26 may further include an open end in the rear direction 28 adapted to accommodate a front front end 31 fixing component of the piston rod 14 in it. Main housing 26 includes a first housing portion 60 containing a first diameter and a second housing portion 62 containing a second diameter larger than the first diameter of the first housing portion 60. A flexible central component 32 is formed within integrally with the main housing 26 adjacent to the closed front end 30. The flexible central component 32 includes a projected portion 34 extending from the front end, a shoulder 64 extending around the first housing portion 60 of the housing main 26, and at least one perimeter edge 66 extending from the second housing portion 62 towards the front end 30 of the main housing 26. The perimeter edge 66 works cooperatively with the shoulder 64 to capture at least one receptacle / air bubble 68 in it. The perimeter edge 66 includes a first rib or damping extending radially 77 along a bit edge portion on the outer surface 74. The method further comprises the following steps: providing at least a second rib 88 extending radially outwardly at the perimeter surrounding an outer diameter portion or second carcass portion 62 of main carcass 26; inserting the front front end fastening member 31 of a piston rod 14 into the open end in the rear direction 28 of the plug 12; applying force to the plunger rod 14 to advance the plug 12 into the syringe container 16 until the projected portion 34 of the flexible central component 32 contacts the bottom or interior surface 36 of an outlet opening, such as Luer 20 ; formation of a seal and trapping of the fluid being prevented from flowing to Luer 20; applying additional force to the piston rod 14 to compress the projected portion 34; advancing the second rib 48 into the syringe container 16; and compressing the trapped air to form an increased pressure inside the air receptacle 68. Upon completion of the unloading operation, the method includes the step of releasing the force close to the piston rod 14 to release the seal between the projected portion 34 and the inner surface 36 of the Luer 20, where the frictional force keeps the second rib 48 in an advanced position inside the syringe container 16 so that the increased pressure inside the air receptacle causes any fluid that has been trapped is propelled through the Luer 20 and is propelled also with any catheter that has been added. When the seal is lost, the pressure and energy stored in the receptacle / air bubble 68 is released. This receptacle / air bubble 68 will expand, forcing the fluid outward from the front of the plug 12. This pressure release drives the flow outward through the Luer 20 causing the fluid to be propelled through any catheter that has been incorporated.
[068] The projected portion 34 of the flexible central component 32 has a profile adapted to create a positive seal with the inner surface of the Luer 20 of the syringe container 16. This flexible central component 32 comes to be interconnected with the main housing 26 via a flexible and / or elastic membrane 44. The step of applying additional force close to the piston rod 14 compresses the projected portion 34 causing the flexible membrane 44 to stretch, while the step of releasing force close to the piston rod Plunger 14 releases this force on the flexible membrane 44 causing any fluid that has been trapped to be propelled through the Luer 20 and also next to any catheter that has been incorporated, preventing reflux from occurring inside the syringe container 16.
[069] The current invention has numerous advantages over existing models for piston rods and plugs. In one aspect of the invention, there is a reduction in the rupture forces present when the plug 12 is initially advanced leading to an easier use of the device and reducing the release that can occur when the plug 12 is first broken. The current models further improve or reduce the support forces close to the plug 12 due to the reduced interference between the breadboard 12 and the syringe container 16 due to the active sealing, which allows the assembly of the piston rod 14 and the buffer 12 to be employed in a wider variety of syringe pumping applications. Yet another advantage of the innovative set is the improved connection between the plunger rod 14 and the plug 12, especially when the plug 12 is inserted into the syringe container 16 before the plunger rod 14 is attached to the plug 12. Previous models used in a threaded connection have a tendency to deform the plug or move it from the center, increasing the chance of leaks. Finally, the innovative model obtains a positive displacement of the fluid after the piston rod 14 has reached the bottom with the release of the force on the piston rod 14.
[070] Taking Fig. 26 as a reference now, which comprises a cross-sectional view of a plug, generally indicated by 270, coming according to a fifth embodiment of the invention, in which the plug 270 comes to be coupled to the piston rod 14. This particular modality differs from the plug models previously described in that an active sealing angle 272 is more closed with the general elevation H2 of plug 279 being shorter due to the elimination of an angle recessed 265, as shown in Figs. 2B, 3, 4B, and 6B, adjacent to the inward protruding portion 274 of the plug 12. Referring again to Fig. 26, the flexible central component 32 includes a front portion 38, a bottom portion 40, and a central portion 42 positioned between the front and bottom portions 38, 40 where the front portion 38 extends beyond the front end 30 of the main housing 26 and with the central portion 42 being interconnected with the main housing 26 via a membrane flexible 44 extending between the flexible central component 32 and the main housing 26. The main housing 26 includes at least one edge extending ahead 50 from a front end of the main housing 26. The edge 50 is adapted to create a positive pressure chamber in it.
[071] Referring again to Fig. 26, the cap 270 includes a main shell 26 defining an open end in the rear direction 28 and a closed front end 30. The open end in the rear direction 28 is adapted for admission of a fixing portion of the front front end 31 of a piston rod 14. The plug 270 further includes a flexible central component 32 formed integrally with the main housing 26 adjacent the closed front end 30. The flexible central component 32 includes a portion designed 34 containing a profile adapted to create a positive seal with an outlet opening (not shown) of the syringe container (not shown). According to the description previously provided, the expression "positive seal" means that the projected portion 34 of the plug fits against the outlet opening, promoting the sealing of this opening without deformation of the projected portion 34. The plug 270 includes at least one rib 46 extending radially outwardly around a perimeter of the main housing 26 to form an active seal with the syringe container.
[072] In this type of configuration, a shoulder portion 274 incorporating an inclined portion 275 is formed on an internal surface 276 of the main housing 26. The inward facing shoulder portion 274 is adapted for contact with the corresponding taper 278 next to a fixing portion of the front front end 31 of the piston rod 14. The tapering 278 of the piston rod 14 and the inclined portion 275 of the inwardly facing shoulder portion 274 cooperate together to form an angle active seal 272 containing an inclination so that the plug 270 will apply a radial force close to at least one rib 46 and to the syringe container 16 by applying a forward force close to the piston rod. The inward-facing protrusion portion 274 includes a first cylindrical wall portion 280 extending toward the closed front end 30 of the main housing 26 containing a uniformly tapered, substantially flat surface profile along the first cylindrical wall portion 280 in this type of embodiment, the recessed portion 265 shown in Figs. 2B, 3, 4B, and 6B have been eliminated, and the overall height H2 (shown in the drawings) of the cap 270 is shorter than the previous developed models. Elimination of the lowered portion 265 also results in an inwardly bounce portion 274 including an inclined portion 275 having a smaller or more closed angle than those shown in the plug models referring to Figs. 2B, 3, 4B, and 6B. This modification of the model can increase the ability to mold the plug and reduce the occurrence of "pulls" of the taper 278 of the piston rod 14 beyond the inward-facing shoulder portion 174 against the front wall of the inner surface 276 of the plug 270. The inward-facing shoulder portion 274 further includes a second cylindrical wall portion 282 extending towards the rear open end 28 of the main housing 26. In one type of arrangement, the inclined portion 275 can extend between the first wall 280 and the second wall 282. The provision of a first wall 280 having a substantially flat surface profile can result in a shorter plug containing a dynamic sealing angle 272 being relatively closed. According to the terminology used in this report, the expression "active sealing angle" refers to the angle or inclination of the inclined surface of the inclined portion plug 275, cooperating with the corresponding stem taper 278 in which the forward force next to the piston rod 14 causes the first rib 46 to form an active seal (as previously defined) with the container wall.
[073] Taking Figs. 27 and 28 showing cross-sectional views of a plug generally indicated as 290 and 310, respectively, coming according to the sixth and seventh modalities of the invention in which the plug 290, 310 comes to be coupled to a stem of the piston 14. According to these modalities, the bottom portion 40 of the flexible central component 32 and / or the inner surface 276 of the closed front end 30 includes at least one groove 292, 312, 313 formed therein. As shown in Fig. 27, a simple groove 292 is provided in the bottom portion 40 of the central flexible core component 32. As shown in Fig. 28, a plurality of grooves 312, 313 are provided concentric together the bottom portion 40 of the flexible central component 32 and the inner surface 276 of the closed front end 30. in these embodiments, the groove 292, 312, 313 is defined at least by a prominence 294, 314, extending towards the ex -front end 296, 316 of the front end end attachment portion 31 of the piston rod 14. The plug material is adapted to contact the front front end 296, 316 of the end portion 31 of the piston rod 14 by applying forward force as shown by the arrow F on the piston rod 14. this tampon material 294, 314 prevents the piston rod 14 and the taper 278 of the rod 14 from sliding forward into the plug 292A, 312A, reducing the amount of pressure near the bottom portion 40 and the central part 42 of the plug and the flexible central component 32.
[074] Now taking Fig. 29 as a reference, which shows a cross-sectional view of a plug and piston rod model according to an alternative model of the invention. According to this model, the assembly consists of a piston rod 324 incorporating a front fixing end 326 and a bottom end 328 extending along a longitudinal axis. The front securing end 326 includes a taper 330 and a front flange 332 extending therefrom. The assembly also includes a plug, indicated by plug 12, containing a main housing 26 defining an open end in the rear direction 28, a closed front end 30, and a flexible central component 32 integrally formed with the main housing 26 adjacent the closed front end 30. The open end in the rear direction 28 is defined by an inner wall surface being adapted for the admission of the front fixing end 326 of the piston rod 324 and locking the piston rod 324 inside the plug 12. At least a rib 46 is provided in the cap 12 extending radially outwardly around the perimeter of the main housing 26 to give an active seal with the syringe container (not shown). A funnel 198 is formed on an internal surface of the main housing 26. This funnel 198 is adapted to contact the inclined portion 331 of the funnel 330 near the front fixing end 326 of the piston rod 324. The contact funnels 198, 330 form an active sealing surface to cooperate together so that the plug 12 applies a radial force to at least one rib 46 and the syringe container by applying a forward force to the plunger rod 324. A space open 334 is defined in the buffer plug 12 by the internal surface of the main housing 26, a portion of the flexible central component 32 and the taper 330 on the internal surface 336 of the main housing 26. The front flange 332 extends from the front end of fixation 326 of the piston rod 324 extends into this open space 334 up to the limit of the path of the piston rod 324 relative to the plug 12 in a longitudinal direction as shown by the arrow L2.
[075] Figs. 30A-30E directed to a plug, generally indicated by 340, according to an eighth embodiment of the invention. The plug 340 is adapted to be attached with the plunger rod 14 shown in Fig. 30C for use inside a syringe container 16 also shown in Fig. 30C. The plug 340 consists of a main housing 26 defining an open end in the rear direction 28 and a closed front end 30. The open end in the rear direction 28 is adapted for admitting a fixing portion of the front front end 31 of the stem plunger 14. The plug 340 further comprises a central component 342 integrally constituted with the main housing 26 adjacent to the closed front end 30. The central component 342 includes a central bottom portion or a central post of buffer 384 defined by a portion side wall 385. According to a type of embodiment, this side wall portion 385 can be essentially straight along its entire length from a base surface 387 of the central buffer post 384 to an intersection 390 where the central post of buffer 384 meets with the bottleneck of buffer 354. This model of straight sidewall 385 can give rise to a reduction in the cost related to usi molding size of buffer 340.
[076] The central component 342 includes a projected portion 344 incorporating a conical tip 346 configured to enter the outlet opening 348 of the syringe container 16. As previously established, according to one embodiment, the central component 342 can further include a station central hollow or solid plug 384, protruding from the inside 342A of the central component 342 towards the open end in the rear direction 28. The central post 384 can be adapted to contact the front front end attachment portion 31 of the stem piston 14. According to a type of embodiment, the main housing 26 can include at least one first rib 349 extending radially outwardly in the perimeter around the main housing 26. The main housing 26 can further include at least one second rib 350 extending radially out of a perimeter around the main housing 26, being spaced from the first rib 349. This first and second ribs 349 and 350 are adapted to give rise to a dynamic seam 352 with the syringe container 16. The main housing 26 may further include a third rib 351 spaced from the first rib 349 and the second rib 350. The first rib 349 , the second rib 350, and the third rib 351 extend radially outwardly at the perimeter around the main housing 26 and can be axially spaced along the main housing 26. The main housing 26 includes at least one recessed portion 55 extending axially into the open end in the rear direction 28. This recessed portion 55 is adapted to lock the front front end attachment portion 31 of the piston rod 14 into the plug 340. The recessed portion 55 may be continuous or segmented. The main housing 26 includes an inner surface containing a taper 353 adapted to contact a corresponding taper 354 near the front front end 31 fixing portion of the piston rod 14. The contact tapers 353, 354 cooperate together so that the plug 349 applies a radial force to the syringe container 16 by applying a forward force to the piston rod 14. According to one embodiment, as shown through Figs. 30A and 30C, the taper 353 of the internal surface of the main housing 26 can consist of a continuous contour showing a curvature from a portion of the side wall 57 of the main housing 26 to the central component 342. The main housing includes a side wall 57 incorporating a first diameter to be contained within a syringe container containing a first portion of inner wall 360, and a tapered tip 346 having a second diameter for contacting the outlet opening of container 348 containing a second portion of inner diameter wall 362. The closed front portion 364 of plug 340 has a profile configured to cooperate with an inner wall of the container 360 containing a tapered wall portion 367 extending between the first and second inner diameter wall portions 360, 362 enabling to a reduction in the main space, shown in Fig. 30C. One embodiment of the plug 340 includes a closed front portion 364 containing a first inclination 369 extending from the projected portion 344 to the first rib 349 which is slightly more staggered than the second inclination 370 of the tapered wall portion of the syringe container 16 extending from the outlet opening 348 of the container 16 to the top sidewall portion 372 of the syringe container 16.
[077] In the embodiment described above shown by Figs. 30A-30E, and especially shown through Fig. 30B, the plug 340 includes an open end in the rear direction 28 defined by an edge portion 29. This edge portion 29 is characterized by a plurality of prominences 341 along its external perimeter. In another embodiment, six prominences 341 may be evenly spaced around the edge portion 29. When the plugs have been stacked together during storage and transportation, or through washing and lubrication procedures, there is a chance that the rear open end 28 and edge portion 29 are positioned on top of the closed front end 30 of another plug. The two plugs may end up sticking to each other and cause failures in the downstream process due to a vacuum occurring in the open chamber of the open end in the rear direction 28 or due to adhesion by the lubricant. The small prominences 341 of the present invention generate space between the plugs 340 preventing them from sticking together.
[078] The invention described above, shown through Figs. 30A-30E comes to a syringe incorporating low dead space and essentially with no reflux. According to the terminology used in this report, the expression "essentially null" means that the displacement of the contents of the container close to the Luer opening, once the forces from the piston rod 14 are removed, is practically zero, minimizing or leading to an essentially zero reflux. To prevent reflux, the conical tip of the plug 346 is designed to contact the outlet opening of the container 348 next to the second portion of the inner diameter wall 362, forming a seal. The angle 369 included in the plug liner can be less than the angle included in container 370, around approximately 1 ° smaller than the angle relative to the angle included in container 370. As shown in Figs 30D and 30E, the first inclination of buffer 369 is compressed by approximately 2.8 ° of greater depth due to nominal interference with container 16 next to first rib 349, second rib 350, and third rib 351. The negative difference between the inclination of buffer 369 and the second inclination of container 370 takes into account the product tolerance of both the plug 369 and the container 16, so that the conical tip 346 of the plug will always contact the outlet opening of the container 348 preventing backflow, minimizing dead space .
[079] As illustrated by Figs. 30C-30E, when the injection force is applied to the piston rod 14, the front front end fixing portion 31 of the piston rod 14 contacts the central post 384 and through it drives the projected portion 344 towards generating a seal in the area where the conical tip 346 of the plug comes in contact with the outlet opening 362, overcoming the increase in pressure in the container as a function of the force of the piston rod. When the contact taper 354 initiates contact with the front front end 31 fixing portion of the piston rod 14, the central post 384 forms an interval 389 between the base surface 387 of the central post 384, as shown in Figs. 30C and 30D, and the front front end attachment portion 31. The interaction between the central plug post 384 and the front front end attachment portion 31 of the piston rod adjusts the distribution of force applied to the piston rod 14 together of the conical end of plug 346 and active seal 352 next to contact funnel 354. Until gap 389 is closed, force is applied next to contact funnel 354, as shown by arrows "A" in Fig. 30D , improving the seal next to the ribs 349 and 350 through a partial deformation of at least the ribs 349, 350 against the container 16. As the force increases, this application is directed to the conical tip 346 through the central post 384, as shown by the arrows "B" in Fig. 30D. In a type of modality, the interval was chosen to be 0.008 "+ / - 0.007", so that the active seal 352 is always dynamic to effect the sealing of the first rib 349 and the second rib 350, being greater than the internal pressure in the container.
[080] The present invention is able to minimize the occurrence and / or relevance of reflux. In one type of modality, the present invention achieves a minimum or "essentially zero" rate of reflux, while still meeting the ISO standard for dead space. In the present invention, shown in the model referring to Figs. 30A-30E, a dead space of less than 100 pL was obtained, such as less than 75 pL or even less than 70 pL. In another modality, a dead space of less than 50 pL, around 48 pL, was obtained. The ISO standard requirement for dead space for 3 ml syringe is 70 pL, for a 5 ml syringe it is 75 pL, and for a 10 ml syringe it is 100 pL. Consequently, a volume of dead space of 48 pL is well within these required standards.
[081] Although the specific modalities of the invention have been described in detail, specialists in the field can observe that several modifications and alternatives to the details presented may be developed in view of the generic teachings provided by this report. Consequently, the particular modalities described seek to be merely illustrative and not to limit the scope of the invention by fully incorporating the attached claims framework and any and all of its equivalent formats.

权利要求:
Claims (23)
[0001]
1. Buffer (340) adapted for attachment to a plunger rod (14) for use inside a syringe container (16), said plug (340) FEATURED for comprising: (a) a main housing (26) defining an open end in the rear direction (28) and a closed front end (30), said open end in the rear direction (28) adapted to receive a fastening portion of the front front end (31) of such piston rod (14), said main housing (26) including an internal surface; (b) a central component (342) formed integrally with said main housing (26) adjacent said closed front end (30), said central component (342) including a projected portion (344) containing a tip conical (346) configured to enter the outlet opening (348) of the syringe container (16), said central component (342) including a central plug post (384) projecting from an interior (342A) of the component center (342) towards the open end in the rear direction (28), said central buffer post (384) including a central bottom portion adapted to contact said front front end fixing portion (31) of the stem plunger (14); (c) at least one first rib (349) extending radially outwardly around a perimeter of said main housing (26); and (d) a taper (353) provided on said internal surface of said main housing (26), said taper (353) adapted to contact a corresponding taper (354) in the front front end fastening portion (31) of the plunger rod (14), said taper (353) and corresponding taper (354) cooperating together to bring the plug (340) to apply a radial force to the syringe container (16) by applying a force front of the piston rod (14).
[0002]
2. Plug (340) according to claim 1, characterized in that it includes at least one second rib (350) extending radially outside a perimeter around said main housing (26), said second rib (350) adapted to form an active seal with such a syringe container (16); and wherein the main housing (26) includes a side wall (57) having a first diameter for containment inside a syringe container (16) having a first internal diameter wall portion (360), the tapered tip (346) having a second diameter to contact the outlet of the container (348) having a second portion of inner diameter wall (362), and the closed front end (364) having a tapered wall profile (367) configured to cooperate with a tapered wall portion of the inner wall of the container extending between the first and second inner diameter wall portions of the container (360, 362) to prevent backflow that reduces the dead space between the plug (340 ) and the inner wall of the container.
[0003]
A plug (340) according to claim 2, CHARACTERIZED by said main frame (26) including at least a third rib (351) and in which said first, second and third ribs (349, 350, 351) extend radially out of a perimeter around said main frame (26) and are axially spaced along said main frame (26).
[0004]
4. Plug (340) according to claim 1, CHARACTERIZED by said main housing (26) to include at least one recessed portion (55) extending axially into said open end in the rear direction (28), said portion recessed (55) adapted for locking such a fastening portion of the front front end (31) of such piston rod (14) present inside said plug (340).
[0005]
5. Buffer (340) according to claim 1, CHARACTERIZED by the fact that said taper (353) of said internal surface of said main housing (26) is a continuous contour from a side wall portion (57 ) of said main housing (26) next to said central component (342).
[0006]
6. Plug (340) according to claim 2, CHARACTERIZED by said front closed end (30) having a first inclination (369) extending from the projected portion (344) to the first rib (349), and with the taper of the syringe container that extends from the outlet opening (348) of the container (16) to a portion of the top side wall (372) of the syringe container (16) showing a second slope (370) where the first slope (369) is more inclined than the second slope (370).
[0007]
7. Plug (340) according to claim 6, CHARACTERIZED by applying a forward force near the piston rod (14), the projected portion (344) of the plug (340) contacting the outlet of the container (348 ) to prevent reflux and the cooperation of the first and second slopes (369, 370) and the radial pressure of the inner wall of the container with respect to at least the first rib (349) inducing the longitudinal extension of the plug (340) so that the projected portion (344) will extend into the outlet of the container (348) preventing the occurrence of reflux.
[0008]
8. Plug (340) according to claim 7, characterized by an angle of the first inclination (369) consisting of approximately 10 less than an angle referring to the second inclination (370).
[0009]
9. Plug (340) according to claim 8, CHARACTERIZED by the longitudinal expansion of the plug (340) by applying a forward force close to the piston rod (14) resulting in an increase in the angle of approximately 2, 8 ° with respect to the first inclination (369).
[0010]
10. Buffer (340) according to claim 1, CHARACTERIZED by the open end in the rear direction (28) being defined through a perimeter edge portion (29), and in which an external surface of the portion of edge (29) includes at least one prominence (341) extending therefrom.
[0011]
11. Buffer (340) according to claim 1, CHARACTERIZED by the central component (342) including a central bottom portion (384) defined by a side wall portion (385) extending from a central surface from base (387) to a tapering surface (354) of the plug (340), the side wall portion (385) being essentially straight substantially along its entire length.
[0012]
12. Syringe, FEATURED for comprising: (a) cylindrical container including a proximal end, a distal end, and a side wall having a first inner diameter (360) extending between the distal and proximal end, said distal end ending in an outlet opening (348) having a second inner diameter (362) which is smaller than said first inner diameter (360), said cylindrical container including a second inclined surface (370) extending between the outlet opening (348 ) and the container side wall; (b) plunger rod (14) capable of expanding into said container through an opening at the proximal end of the container, said plunger rod (14) including a front front attachment portion (31); and (c) buffer (340) containing a main housing (26) having an open end in the rear direction (28), a closed front end (30), and a side wall portion extending between said open end in rear direction and said closed front end, said open end in the rear direction (28) adapted to receive said front front fixing portion (31) of such piston rod (14), with a central component (342) being integrally formed with said main housing (26) adjacent said closed front end (30), said central component (342) including a projected portion (344) incorporating a conical tip (346) configured to enter the outlet opening (348) of the syringe container (16), said central component (342) including a central plug post (384) projecting from inside (342A) of the central component (342) towards the open end in the rear direction (28), said central plug post (384) including a central bottom portion adapted to contact said front front end fixing portion (31) of the piston rod (14), said closed front end ( 30) including a first inclined surface (369) extending from the conical tip (346) to said side buffer portion, said first inclined surface (369) of said buffer (340) being more inclined than the second inclined surface (370) of the cylindrical container (16) so that the application of a forward force next to said piston rod (14) leads to the conical tip (346) of the plug (340) between in the outlet opening (348) resulting essentially in a zero reflux, and in which the first and second inclinations (369, 370) cooperate to reduce the dead space present inside the container (16), and in which said housing main (26) includes an int surface core containing a taper (353) adapted to contact a corresponding taper (354) in the front front end fixing portion (31) of such plunger rod (14), said taper (353) and corresponding taper (354) ) cooperating together so that said plug (340) applies a radial force to the syringe container (16) by applying a forward force close to the plunger rod (14).
[0013]
13. A syringe according to claim 12, characterized by the main housing (26) including a first rib (349) extending radially outside a perimeter around said main housing (26), and at least a second rib ( 350) extending radially out of a perimeter around said main housing (26) away from said first rib (349), and with at least said second rib (350) being adapted to form an active seal with the syringe container (16).
[0014]
The syringe according to claim 12, CHARACTERIZED by said tapering (353) of said inner surface of said main housing (26) consisting of a continuous contour from a side wall portion (57) of said main housing main (26) to said central component (343).
[0015]
A syringe according to claim 12, CHARACTERIZED by said main housing (26) to include at least one recessed portion (55) extending axially inward from said open end in the rear direction (30), with said portion recessed (55) adapted to lock the front portion (31) of such piston rod (14) inside said plug (340).
[0016]
16. Syringe, according to claim 12, CHARACTERIZED by applying a forward force close to the plunger rod (14), the projected portion (344) of the plug (340) will contact the outlet of the container (348) to prevent reflux and come to cooperate with the first and second slopes (369, 370) and the radial pressure of the inner wall of the container with respect to at least the first rib (349) will induce a longitudinal extension of the plug (340) so that the projected portion (344) will extend into the outlet of the container (348) preventing the occurrence of reflux.
[0017]
17. Syringe, according to claim 16, characterized by an angle of the first inclination (369) being at least 10 less than the angle of the second inclination (370) and in which the longitudinal expansion of the plug (340) by means of the application of a forward force near the piston rod (14) results in an angle increase of approximately 2.8 ° in relation to the first inclination (369).
[0018]
18. Buffer (270) adapted for fastening next to a plunger rod (14) for use inside a syringe container (16), with said buffer (270) FEATURED for comprising: (a) a main housing (26 ) defining an open end in the rear direction (28) and a closed front end (30), said open end in the rear direction (28) adapted for admitting a front front end fixing portion (31) of such rod plunger (14); (b) a central component (32) integrally formed with said main housing (26) adjacent said closed front end (30), said central component (32) including a projected portion (34), said central component (32) including a central buffer station projecting from an interior of the central component (32) towards the open end in the rear direction (28), said central buffer station including a central bottom portion (40) adapted for contacting said fastening portion of the front front end (31) of the piston rod (14), said projected portion (34) having a profile adapted to create a positive seal with an outlet opening (20 ) of such a syringe container (16); (c) at least one rib (46) extending radially outwardly around a perimeter of said main housing (26) to form an active seal with such a syringe container (16); and (d) inwardly facing shoulder portion (274) on an internal surface (276) of said main housing (26), said internal shoulder portion (274) adapted to contact the taper (278) at the front end (31) ) of the piston rod (14), in which the contact of the said inwardly directed shoulder portion (274) with the re-wound taper (278) causing the plug (270) to apply a radial force at least a said rib (46) and in the syringe container (16) by applying a forward force close to the plunger rod (14), and said inwardly pointing shoulder portion (274) includes a first wall portion cylindrical (280) extending from the closed front end (30) of said main housing (26), said first wall portion (280) having a substantially flat surface profile, said protruding inward portion (274 ) further including a second cylindrical wall portion single (282) extending towards the open end towards the rear (28) of said main housing (26), and an inclined portion (275) extending between the first wall (280) and the second wall (282).
[0019]
19. Plug (270) according to claim 18, characterized by the central component (32) including a front portion (38), a bottom portion (40), and a central portion (42) positioned between said front portion and the bottom one, with said front portion extending beyond the front end (30) of said main housing (26) and with said central portion (42) being interconnected with said main housing (26) via a flexible membrane ( 44) extending between said central component and said main housing (26).
[0020]
20. Cap (270) according to claim 18, CHARACTERIZED by said main frame (26) to include at least one edge (50) extending ahead from a front end (30) of said main frame (26) where said edge (50) is adapted to create a positive pressure chamber therein.
[0021]
21. Buffer (270) according to claim 18, characterized by said central component (32) including a bottom portion (40) in which at least one said bottom portion (40) of said central component (32) and an inner surface (276) of said closed front end (30) includes at least one concentric groove (292, 312, 313) formed therein.
[0022]
22. Plug (270) according to claim 21, characterized by at least said bottom portion (40) of said central component (32) and said inner surface (276) of said closed front wall (30) include plug material (294, 314) adapted to contact the front front end fastening portion (31) of the piston rod (14) by applying forward force close to the piston rod (14).
[0023]
23. Plunger plug and stem assembly adapted for use with a syringe container, said assembly FEATURED for comprising: (a) plunger stem (324) containing a front clamping end (326) and a bottom end (328) ) extending along a longitudinal axis, said front fixing ex-tremity (326) including a taper (330) and a front flange (332) extending therefrom; (b) plug (12) containing a main housing (26) defining an open end in the rear direction (28), a closed front end (30), and a central component (32) integrally formed with said main housing (26) adjacent said closed front end (30), said central component (32) including a central plug post projecting from inside the central component (32) towards the open end in the rear direction (28), said central buffer post including a central bottom portion adapted to contact said front fixing end (326) of the plunger rod (324), said open end in the rear direction (28) defined through a wall surface internal, said open end adapted for the admission of said front fixing end (326) of said piston rod (324) and locking said piston rod (324) inside said plug (12); (c) at least one rib (46) extending radially outwardly around a perimeter of said main housing (26) to form an active seal with the syringe container (16); (d) funnel (198) formed on an internal surface of said main housing (26), said funnel having an inclined portion adapted for contact with said funnel (330) at the front fixing end (326) of such has plunger (324), said contact tapers (198, 330) forming an active sealing surface for joint cooperation causing the said plug (12) to apply a radial force to at least one said rib (46) and the container syringe by applying a forward force close to the plunger rod (324); and (e) an open space (334) defined by the internal surface (336) of the main housing (26), a portion of said central component (32), and said taper (330) on the internal surface (336) of said housing main (26), wherein said front flange (332) extending from said front securing end (326) of said piston rod (324) extends into said open space (334).

类似技术:

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同族专利:

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公开号 | 公开日

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JP5814342B2|2015-11-17|

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JP2013523330A|2013-06-17|

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EP2555817A2|2013-02-13|

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JP2019130387A|2019-08-08|

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CA2794206A1|2011-10-13|

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US9592346B2|2017-03-14|

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JP2017148554A|2017-08-31|

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ES2808327T3|2021-02-26|

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CA2794206C|2015-06-09|

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AU2011238758A1|2012-10-25|

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US8740856B2|2014-06-03|

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US10183118B2|2019-01-22|

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CN102971031A|2013-03-13|

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WO2011126764A3|2011-12-01|

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CN102971031B|2016-01-27|

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US20170136187A1|2017-05-18|

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WO2011126764A2|2011-10-13|

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JP2016013471A|2016-01-28|

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BR112012025548A2|2016-06-28|

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JP6514265B2|2019-05-15|

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AU2011238758B2|2014-11-06|

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EP2555817B1|2020-05-13|

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US20110034882A1|2011-02-10|

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JP6133953B2|2017-05-24|

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US20140207081A1|2014-07-24|

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MX2012010943A|2013-02-07|

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JP6959699B2|2021-11-05|

引用文献:

---

公开号 | 申请日 | 公开日 | 申请人 | 专利标题

---

---

US2895773A|1956-10-22|1959-07-21|Robert K Mcconnaughey|Variable diameter tensed ring piston|

---

US3176595A|1963-05-22|1965-04-06|Galland Henning Mfg Company|Plastic piston assembly|

---

FR1500009A|1966-05-27|1967-11-03|Sodip Sa|Syringe development|

---

DE2024117B1|1970-05-16|1971-09-16|Hampel, Heinz, 7071 Lindach|Injection syringe|

---

US3809082A|1971-12-30|1974-05-07|Ampoules Inc|Plunger tack|

---

US3939833A|1975-01-15|1976-02-24|Astra Pharmaceutical Products Inc.|Piston construction for syringes|

---

US4266557A|1978-01-16|1981-05-12|The Kendall Company|Low friction syringe|

---

US4354507A|1978-01-17|1982-10-19|Concord Laboratories|Syringe|

---

US4215701A|1978-08-21|1980-08-05|Concord Laboratories, Inc.|Elastomeric plunger tip for a syringe|

---

US4500310A|1982-12-20|1985-02-19|Becton, Dickinson And Company|Variable sealing pressure plunger rod assembly|

---

US4543093A|1982-12-20|1985-09-24|Becton, Dickinson And Company|Variable sealing pressure plunger rod assembly|

---

US4687467A|1986-06-11|1987-08-18|C.T.F. Research Company|One-time use medical syringe invention|

---

US4973308A|1987-05-22|1990-11-27|Ramon M. Rovira|Injection syringe with mechanism preventing reuse|

---

US4931043A|1988-08-08|1990-06-05|Sterling Drug Inc.|Ratchet connector for hypodermic syringe pistons|

---

US5201709A|1989-06-16|1993-04-13|Capra Nicholas G|Single use, self destructing disposable syringe|

---

US4986820A|1989-06-23|1991-01-22|Ultradent Products, Inc.|Syringe apparatus having improved plunger|

---

US5246423A|1991-11-01|1993-09-21|Farkas Paul J|Remote cannula removal hypodermic syringe|

---

US5195975A|1992-01-15|1993-03-23|Castagna John F|Single use hypodermic syringe|

---

US5314416A|1992-06-22|1994-05-24|Sherwood Medical Company|Low friction syring assembly|

---

DE4339528C2|1993-11-19|1995-09-07|Freudenberg Carl Fa|Disposable syringe|

---

US5395345A|1994-01-27|1995-03-07|The Kendall Company|Aspirating syringe|

---

US5397313A|1994-01-27|1995-03-14|The Kendall Company|Low friction syringe|

---

US5795337A|1994-02-14|1998-08-18|Becton Dickinson And Company|Syringe assembly and syringe stopper|

---

US5411488A|1994-05-06|1995-05-02|Sterling Winthrop Inc.|Pre-filled syringe and pre-filled cartridge having an improved plunger and plunger rod for reducing syringing force|

---

US5411489A|1994-05-06|1995-05-02|Sterling Winthrop Inc.|Pre-filled syringe and pre-filled cartridge having actuating cylinder/plunger rod combination for reducing syringing force|

---

JP3383966B2|1994-05-27|2003-03-10|ニプロ株式会社|Prefilled syringe|

---

US5722951A|1994-07-14|1998-03-03|Marano; Carlos Jose|Hypodermic non-reusable syringes without voluntary intervention of the user|

---

US5688252A|1994-09-30|1997-11-18|Takeda Chemical Industries, Ltd.|Syringe|

---

US5735825A|1996-03-22|1998-04-07|Merit Medical Systems, Inc.|Syringe plunger tip|

---

US5865798A|1996-06-28|1999-02-02|Becton Dickinson France, S.A.|Stopper assembly having bypass features for use in a multi-chamber syringe barrel|

---

US5713857A|1996-06-28|1998-02-03|Becton Dickinson France, S.A.|Sequential stopper|

---

US5873861A|1996-11-12|1999-02-23|Medrad, Inc.|Plunger systems|

---

US6053894A|1997-08-04|2000-04-25|Shadd, Jr.; Daniel L.|Hypodermic syringe|

---

US6261524B1|1999-01-12|2001-07-17|Advanced Technology Materials, Inc.|Advanced apparatus for abatement of gaseous pollutants|

---

US6224577B1|1998-03-02|2001-05-01|Medrad, Inc.|Syringes and plungers for use therein|

---

US6361524B1|1998-04-14|2002-03-26|Becton, Dickinson And Company|Syringe assembly|

---

JP2000107993A|1998-10-06|2000-04-18|Fujitsu Ltd|Production management system, its recovery method, and recording medium having program therefor stored therein|

---

US6171286B1|1999-04-20|2001-01-09|James R. Gross|Self-aligning syringe plunger|

---

JP4370045B2|2000-06-21|2009-11-25|大成化工株式会社|Syringe|

---

EP1180377A1|2000-08-16|2002-02-20|Schering Aktiengesellschaft|Syringe with piston|

---

JP2002086481A|2000-09-14|2002-03-26|Terumo Corp|Method for manufacturing gasket|

---

US6511459B1|2000-09-29|2003-01-28|Mallinckrodt Inc.|Syringe plunger having an improved sealing ability|

---

JP2002159574A|2000-11-22|2002-06-04|Terumo Corp|Gasket and syringe|

---

JP2002263187A|2001-03-08|2002-09-17|Terumo Corp|Gasket and syringe|

---

US6991618B2|2001-09-24|2006-01-31|Becton Dickinson And Company|Single use syringe and plunger rod locking device therefor|

---

AU2003281199A1|2002-07-02|2004-01-23|Terumo Kabushiki Kaisha|Syringe and prefilled syringe|

---

US6872191B2|2002-07-08|2005-03-29|M.K. Meditech Co., Ltd.|Self-destructive syringe|

---

US20040010235A1|2002-07-11|2004-01-15|Weilbacher Eugene E.|Anti-reflux syringe|

---

ES2683877T3|2002-10-11|2018-09-28|Becton, Dickinson And Company|Washing syringe with compressible piston|

---

US6821266B2|2002-11-12|2004-11-23|U.S. Technology, Inc.|Syringe|

---

US20040127859A1|2002-12-26|2004-07-01|Ward Michael Terrance|Anti-reflux syringe|

---

JP2004283466A|2003-03-24|2004-10-14|Terumo Corp|Plunger with gasket for syringe, syringe and prefilled syringe|

---

FR2855413B1|2003-05-26|2005-12-30|Becton Dickinson France|PRE-FILLED SYRINGE WITH ANTI-EFFRACTION COIFFE|

---

DE10330094B4|2003-07-03|2008-04-17|Disetronic Licensing Ag|Device for administering a liquid product|

---

US7056301B2|2003-09-05|2006-06-06|Jung-O Liu|Syringe|

---

US7534233B2|2003-09-23|2009-05-19|Becton, Dickson And Company|Flush syringe having anti-reflux features|

---

US20050063857A1|2003-09-23|2005-03-24|Alheidt Thomas A.|Flush syringe having anti-reflux stopper|

---

US7331942B2|2003-09-23|2008-02-19|Becton, Dickinson And Company|Flush syringe having anti-reflux stopper|

---

US20050154353A1|2004-01-09|2005-07-14|Alheidt Thomas A.|Positive displacement flush syringe|

---

ES2764664T3|2004-01-09|2020-06-04|Becton Dickinson Co|Positive displacement rinse syringe|

---

US9522237B2|2005-01-07|2016-12-20|Becton, Dickinson And Company|Positive displacement flush syringe|

---

US7955309B2|2005-04-13|2011-06-07|Coeur, Inc.|Syringe plunger jacket with expandable seal|

---

CA2830554C|2007-06-04|2016-05-31|Becton, Dickinson And Company|Positive displacement stopper for a pre-filled syringe|

---

US8740856B2|2007-06-04|2014-06-03|Becton, Dickinson And Company|Stoppers used in pre-filled syringes|AUPQ867900A0|2000-07-10|2000-08-03|Medrad, Inc.|Medical injector system|

---

USD942005S1|2007-03-14|2022-01-25|Bayer Healthcare Llc|Orange syringe plunger cover|

---

US7666169B2|2003-11-25|2010-02-23|Medrad, Inc.|Syringe and syringe plungers for use with medical injectors|

---

US8926569B2|2006-03-15|2015-01-06|Bayer Medical Care Inc.|Plunger covers and plungers for use in syringes and methods of fabricating plunger covers and plungers for use in syringes|

---

USD847985S1|2007-03-14|2019-05-07|Bayer Healthcare Llc|Syringe plunger cover|

---

US8740856B2|2007-06-04|2014-06-03|Becton, Dickinson And Company|Stoppers used in pre-filled syringes|

---

WO2011121867A1|2010-03-29|2011-10-06|テルモ株式会社|Prefilled syringe|

---

CN103608056A|2011-04-20|2014-02-26|诺沃—诺迪斯克保健股份有限公司|Piston rod anchoring|

---

US9333288B2|2011-09-30|2016-05-10|Becton Dickinson France, S.A.S.|Attachable plunger rod and associated packaging|

---

RS56346B1|2011-10-19|2017-12-29|Medtron Ag|Syringe for a high pressure injector|

---

ITRE20120020A1|2012-03-14|2013-09-15|Cgm Spa|SYRINGE FOR THE INJECTION OF SOLID GRANULAR MATERIAL|

---

US9174003B2|2012-09-28|2015-11-03|Bayer Medical Care Inc.|Quick release plunger|

---

US9233208B2|2012-11-29|2016-01-12|Becton, Dickinson And Company|Methods and apparatus for disinfecting and reflux prevention flush syringe assembly|

---

JP6395707B2|2013-06-06|2018-09-26|テルモ株式会社|Syringes and prefilled syringes|

---

US10561795B2|2013-10-07|2020-02-18|Sio2 Medical Products, Inc.|Convertible plungers, film coated plungers and related syringe assemblies|

---

AU2014360486B2|2013-12-06|2019-08-22|Genentech, Inc.|Apparatus and methods for low-volume medicament delivery|

---

DK3119453T3|2014-03-19|2019-04-15|Bayer Healthcare Llc|SYSTEM FOR SPRAY INTERVENTION FOR AN INJECTOR|

---

US20170021108A1|2014-04-02|2017-01-26|Aptar Stelmi Sas|Anti-reflux syringe assembly|

---

CA2960135A1|2014-09-10|2016-03-17|Sio2 Medical Products, Inc.|Three-position plungers, film coated plungers and related syringe assemblies|

---

US10196196B2|2014-09-11|2019-02-05|Vcxt, Llc|Watertight liquid dispenser with syringe-like functions|

---

FR3032123B1|2015-01-29|2021-04-23|Aptar Stelmi Sas|SYRINGE PLUG-PLUG.|

---

US10835681B2|2015-03-24|2020-11-17|Becton, Dickinson And Company|Time-of-use activated syringe stopper|

---

CN107427645B|2015-03-27|2021-05-25|诺和诺德股份有限公司|Deformable piston washer|

---

US10765812B2|2015-07-14|2020-09-08|Sio2 Medical Products, Inc.|Convertible plungers and methods for assembling the same in a medical barrel|

---

US10918800B2|2016-05-31|2021-02-16|Sio2 Medical Products, Inc.|Convertible plungers and methods for assembling the same in a medical barrel|

---

US11266786B2|2015-08-13|2022-03-08|Shl Medical Ag|Stopper for a medicament container|

---

CA2996863C|2015-09-01|2021-04-13|Becton, Dickinson And Company|Depth filtration device for separating specimen phases|

---

US9480797B1|2015-10-28|2016-11-01|Bayer Healthcare Llc|System and method for syringe plunger engagement with an injector|

---

US10668215B2|2015-12-30|2020-06-02|Baxter Corporation Englewood|Tip cap for automatic syringe filling apparatus|

---

JP2019508077A|2016-01-21|2019-03-28|メリット・メディカル・システムズ・インコーポレイテッドＭｅｒｉｔ Ｍｅｄｉｃａｌ Ｓｙｓｔｅｍｓ，Ｉｎｃ．|Covering for a syringe plunger tip and method therefor|

---

WO2017127534A1|2016-01-21|2017-07-27|Merit Medical Systems, Inc.|Partially lubricated syringe barrels, plungers, and seal members and related methods|

---

US10286151B2|2016-02-26|2019-05-14|West Pharma. Services IL, Ltd.|Plunger with reduced leakage during storage|

---

JP6830484B2|2016-06-30|2021-02-17|クラレノリタケデンタル株式会社|dispenser|

---

CN206837199U|2016-12-05|2018-01-05|甘肃成纪生物药业有限公司|A kind of delivery device and its retreating prevention mechanism|

---

USD870278S1|2017-01-13|2019-12-17|Sio2 Medical Products, Inc.|Syringe plunger assembly|

---

US20200023135A1|2017-02-17|2020-01-23|Becton, Dickinson And Company|Syringe and plunger rod with stopper guide|

---

EP3501570A1|2017-12-22|2019-06-26|Sensile Medical AG|Drug delivery device with container having a plunger|

---

JP2019217106A|2018-06-21|2019-12-26|株式会社松風|Injector|

---

EP3943133A1|2019-03-29|2022-01-26|TERUMO Kabushiki Kaisha|Plunger kit, syringe kit, and prefilled syringe|

---

WO2021180824A1|2020-03-11|2021-09-16|Becton Dickinson France|Plunger rod and syringe including same|

---

FR3112962A1|2020-07-31|2022-02-04|Laboratoires Vivacy|High pull strength syringe|

法律状态:
2019-01-08| B06F| Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]|

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2019-08-13| B06U| Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]|

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2020-06-02| B06A| Patent application procedure suspended [chapter 6.1 patent gazette]|

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2020-09-15| B09A| Decision: intention to grant [chapter 9.1 patent gazette]|

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2020-10-27| B16A| Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]|Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 25/03/2011, OBSERVADAS AS CONDICOES LEGAIS. |

优先权:

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申请号 | 申请日 | 专利标题

---

US12/754,101|2010-04-05|

---

US12/754,101|US8740856B2|2007-06-04|2010-04-05|Stoppers used in pre-filled syringes|

---

PCT/US2011/029933|WO2011126764A2|2010-04-05|2011-03-25|Stoppers used in pre-filled syringes|

---